LncRNA-mRNA Co-Expression Analysis Identifies AL133346.1/CCN2 as Biomarkers in Pediatric B-Cell Acute Lymphoblastic Leukemia

Pediatric acute B-cell lymphoblastic leukemia (B-ALL) constitutes a heterogeneous and aggressive neoplasia in which new targeted therapies are required. Long non-coding RNAs have recently emerged as promising disease-specific biomarkers for the clinic. Here, we identified pediatric B-ALL-specific ln...

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Bibliographic Details
Published in:Cancers 2020-12, Vol.12 (12), p.3803
Main Authors: Cuadros, Marta, García, Daniel J, Andrades, Alvaro, Arenas, Alberto M, Coira, Isabel F, Baliñas-Gavira, Carlos, Peinado, Paola, Rodríguez, María I, Álvarez-Pérez, Juan Carlos, Ruiz-Cabello, Francisco, Camós, Mireia, Jiménez-Velasco, Antonio, Medina, Pedro P
Format: Article
Language:English
Subjects:
Acute lymphoblastic leukemia
Biomarkers
Bone marrow
Cancer
Cell survival
Communication
Connective tissue growth factor
Disease
Gene expression
Leukemia
Lymphatic leukemia
Lymphocytes B
Medical prognosis
Non-coding RNA
Ontology
Pediatrics
Proteins
Signal transduction
Transcriptomics
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Summary:Pediatric acute B-cell lymphoblastic leukemia (B-ALL) constitutes a heterogeneous and aggressive neoplasia in which new targeted therapies are required. Long non-coding RNAs have recently emerged as promising disease-specific biomarkers for the clinic. Here, we identified pediatric B-ALL-specific lncRNAs and associated mRNAs by comparing the transcriptomic signatures of tumoral and non-tumoral samples. We identified 48 lncRNAs that were differentially expressed between pediatric B-ALL and healthy bone marrow samples. The most relevant lncRNA/mRNA pair was AL133346.1/CCN2 (previously known as RP11-69I8.3/CTGF), whose expression was positively correlated and increased in B-ALL samples. Their differential expression pattern and their strong correlation were validated in external B-ALL datasets (Therapeutically Applicable Research to Generate Effective Treatments, Cancer Cell Line Encyclopedia). Survival curve analysis demonstrated that patients with "high" expression levels of CCN2 had higher overall survival than those with "low" levels ( = 0.042), and this gene might be an independent prognostic biomarker in pediatric B-ALL. These findings provide one of the first detailed descriptions of lncRNA expression profiles in pediatric B-ALL and indicate that these potential biomarkers could help in the classification of leukemia subtypes and that CCN2 expression could predict the survival outcome of pediatric B-cell acute lymphoblastic leukemia patients.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers12123803