The Role of Bone Scintigraphy with SPECT/CT in the Characterization and Early Diagnosis of Stage 0 Charcot Neuroarthropathy

We describe the use of Single Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) in the investigation and diagnosis of Charcot neuroarthropathy (CN) in patients with a hot swollen foot but normal radiographs and clinical suspicion of CN, usually termed Stage 0. This was a retrospecti...

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Bibliographic Details
Published in:Journal of clinical medicine 2020-12, Vol.9 (12), p.4123
Main Authors: Ahluwalia, Raju, Bilal, Ahmad, Petrova, Nina, Boddhu, Krishna, Manu, Chris, Vas, Prashanth, Bates, Maureen, Corcoran, Ben, Reichert, Ines, Mulholland, Nicola, Kavarthapu, Venu, Vivian, Gill, Edmonds, Michael
Format: Article
Language:English
Subjects:
Bones
Clinical medicine
Cysts
Diabetes
Diabetic neuropathy
Foot diseases
Fractures
Medical imaging
Nuclear medicine
Scintigraphy
Tomography
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Summary:We describe the use of Single Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) in the investigation and diagnosis of Charcot neuroarthropathy (CN) in patients with a hot swollen foot but normal radiographs and clinical suspicion of CN, usually termed Stage 0. This was a retrospective cohort review of 46 diabetes patients who underwent 3 phase bone scintigraphy with "High Resolution" SPECT/CT. The imaging demonstrated that Stage 0 Charcot foot has a distinct bone pathology, which can be classified into three groups: (1) fractures on Computed Tomography (CT) with accompanying focal uptake of tracer on SPECT, (2) bony abnormalities apart from fracture on CT with focal uptake of tracer on SPECT, and (3) normal CT but focal bony uptake of tracer on SPECT. The CT component of SPECT/CT detected bony fractures in 59% of patients. Early treatment with below knee cast and follow-up for 24 months showed only 4 patients who developed Stage 1 Eichenholtz Charcot foot. Our findings support the use of 3 phase bone scintigraphy with SPECT/CT in the characterization and early diagnosis of CN. Stage 0 Charcot foot has a distinct bone pathology which requires urgent treatment to prevent progression to Stage 1 Eichenholtz Charcot foot. If SPECT/CT is unavailable, CT alone will detect bone fracture in 59% patients.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm9124123