TLR9 Rs352140 polymorphism contributes to a decreased risk of bacterial meningitis: evidence from a meta-analysis

Some studies have suggested that the Toll-like receptor 9 polymorphism (TLR9 rs352140) is closely related to the risk of bacterial meningitis (BM), but this is subject to controversy. This study set out to estimate whether the TLR9 rs352140 polymorphism confers an increased risk of BM. Relevant lite...

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Bibliographic Details
Published in:Epidemiology and infection 2020-11, Vol.148, p.e294-e294, Article e294
Main Authors: Xue, Haiyi, Peng, Huan, Li, Jiaoming, Li, Mingming, Lu, Song
Format: Article
Language:English
Subjects:
Bacteria - classification
Bacterial infections
Bacterial Infections - genetics
Bacterial Infections - metabolism
Bias
Confidence intervals
Cytokines
Fatalities
Genetic Predisposition to Disease
Health risks
Heterozygotes
Humans
Investigations
Meningitis
Meningitis, Bacterial - genetics
Meta-analysis
Mortality
Nervous system
Odds Ratio
Original Paper
Polymorphism
Polymorphism, Single Nucleotide
Risk
Streptococcus infections
Target recognition
TLR9 protein
Toll-Like Receptor 9 - genetics
Toll-Like Receptor 9 - metabolism
Toll-like receptors
Tuberculosis
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Summary:Some studies have suggested that the Toll-like receptor 9 polymorphism (TLR9 rs352140) is closely related to the risk of bacterial meningitis (BM), but this is subject to controversy. This study set out to estimate whether the TLR9 rs352140 polymorphism confers an increased risk of BM. Relevant literature databases were searched including PubMed, Embase, the Cochrane Library and China National Knowledge Infrastructure (CNKI) up to August 2020. Seven case-control studies from four publications were enrolled in the present meta-analysis. Odds ratios (OR) and confidence intervals (95% CI) were calculated to estimate associations between BM risk and the target polymorphism. Significant associations identified were allele contrast (A vs. G: OR 0.66, 95% CI 0.59–0.75, P = 0.000), homozygote comparison (AA vs. AG/GG: OR 0.62, 95% CI 0.49–0.78, P = 0.000), heterozygote comparison (A vs. G: OR 0.74, 95% CI 0.61–0.91, P = 0.005), recessive genetic model (AA vs. AG/GG: OR 0.78, 95% CI 0.65–0.93, P = 0.006) and dominant genetic model (AA vs. AG/GG: OR 0.70, 95% CI 0.57–0.85, P = 0.000). The findings indicate that, in contrast to some studies, the TLR9 rs352140 polymorphism is associated with a decreased risk for BM.
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268820002666