Structural Responses of Integrated Parametric Aortic Valve in an Electro-Mechanical Full Heart Model

The aortic valve (AV) is located between the left ventricle and the aorta and responsible for maintaining an outward unidirectional flow. Many AV hemodynamic and structural aspects of have been extensively studied, however, more sophisticated models are needed to better understand the AV biomechanic...

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Bibliographic Details
Published in:Annals of biomedical engineering 2021-01, Vol.49 (1), p.441-454
Main Authors: Morany, Adi, Lavon, Karin, Bluestein, Danny, Hamdan, Ashraf, Haj-Ali, Rami
Format: Article
Language:English
Subjects:
Adult
Aorta
Aortic valve
Biochemistry
Biological and Medical Physics
Biomechanical Phenomena
Biomechanics
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Biophysics
Boundary conditions
Classical Mechanics
Computed tomography
Computed Tomography Angiography
Computer Simulation
Confidence
Correlation analysis
Diameters
Ellipticity
Finite Element Analysis
Finite element method
Heart
Heart - diagnostic imaging
Heart - physiology
Heart valves
Hemodynamics
Humans
Male
Mathematical models
Models, Cardiovascular
Original Article
Stress, Mechanical
Stresses
Structural models
Ventricle
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Summary:The aortic valve (AV) is located between the left ventricle and the aorta and responsible for maintaining an outward unidirectional flow. Many AV hemodynamic and structural aspects of have been extensively studied, however, more sophisticated models are needed to better understand the AV biomechanical behavior. This study deals with integrating a new parametric AV structural model with the electro-mechanical Living Heart Human Model® (LHHM). The LHHM is a finite element model simulating human heart capable of realistic electro-mechanical simulations. Different geometric metrics of AV have been examined. New integrated structural AV model within the LHHM better predict local stresses during the cardiac cycle due to the realistic boundary condition derived from the LHHM. It was found that ellipticity index (EI), calculated as the ratio between the maximal (Max) and minimal (Min) aortic annulus (AA) diameters, well correlates with measured clinical data obtained from patients undergoing computed tomography (CT) while the annular perimeter (Perim) matches the same trend. This increases the confidence in the predicted kinematic behavior, leaflets coaptation, and the overall stresses. From the clinical aspect, the new proposed coupled and integrated AV modeling can serve as a platform for design and implementation of pre-transcatheter aortic valve replacement (TAVR) procedures.
ISSN:0090-6964
1573-9686
DOI:10.1007/s10439-020-02575-0