Influenza in Children

Influenza poses a significant disease burden on children worldwide, with high rates of hospitalization and substantial morbidity and mortality. Although the clinical presentation of influenza in children has similarities to that seen in adults, there are unique aspects to how children present with i...

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Bibliographic Details
Published in:Cold Spring Harbor perspectives in medicine 2021-01, Vol.11 (1), p.a038430
Main Authors: Nayak, Jennifer, Hoy, Gregory, Gordon, Aubree
Format: Article
Language:English
Subjects:
Child
Humans
Influenza Vaccines - immunology
Influenza, Human - immunology
Influenza, Human - prevention & control
Influenza, Human - transmission
Morbidity
Vaccination
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Summary:Influenza poses a significant disease burden on children worldwide, with high rates of hospitalization and substantial morbidity and mortality. Although the clinical presentation of influenza in children has similarities to that seen in adults, there are unique aspects to how children present with infection that are important to recognize. In addition, children play a significant role in viral transmission within communities. Growing evidence supports the idea that early influenza infection can uniquely establish lasting immunologic memory, making an understanding of how viral immunity develops in this population critical to better protect children from infection and to facilitate efforts to develop a more universally protective influenza vaccine.
ISSN:2157-1422
2472-5412
DOI:10.1101/cshperspect.a038430