A High-Grade Glioma of Temporal Lobe in a Child: A Case Report and Literature Review

High-grade glioma is also called a malignant glioma because it is fast-growing and spread rapidly through brain tissue. Due to the rarity of high-grade glioma, its diagnosis and management are multi-faceted. We present a case of a 10-year-old girl presented with headache, seizure, and right-sided we...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2020-11, Vol.12 (11), p.e11802
Main Authors: Khan, Aadil M, Dawe, Manal, Shahnawaz, Warda, Saleem, Muhammad W, Ahmed, Zahoor
Format: Article
Language:English
Subjects:
Neurology
Oncology
Pediatrics
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Summary:High-grade glioma is also called a malignant glioma because it is fast-growing and spread rapidly through brain tissue. Due to the rarity of high-grade glioma, its diagnosis and management are multi-faceted. We present a case of a 10-year-old girl presented with headache, seizure, and right-sided weakness of upper and lower limbs. Neurological exam revealed reduced power in both upper and lower right limbs with reduced sensation and reflexes. Magnetic resonance imaging revealed an ill-defined altered signal intensity mass involving the left temporal lobe with parenchymal involvement and surrounding perilesional vasogenic edema. Biopsy of the lesion confirmed high-grade glioma. The patient underwent external beam radiation therapy with concomitant daily temozolomide treatment, followed by adjuvant standard temozolomide. However, progressive neurological worsening and an increased lesion size led to partial tumor resection through a craniotomy to remove intracranial hypertension, which was unsuccessful, and the patient could not survive after the procedure.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.11802