Prevalence of asymptomatic COVID-19 infection using a seroepidemiological survey

The prevalence of asymptomatic infection by coronavirus disease 2019 (COVID-19) as a critical measure for effectiveness of mitigation strategy has been reported to be widely varied. In this study, we aimed to determine the prevalence of asymptomatic infection using serosurvey on general population....

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Bibliographic Details
Published in:Epidemiology & Infection 2020-11, Vol.148, p.e300-e300, Article e300
Main Authors: Shakiba, M., Nazemipour, M., Heidarzadeh, A., Mansournia, M. A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Aged
Antibodies
Asymptomatic
Asymptomatic infection
Bias
Carrier State
Child
Child, Preschool
Confidence intervals
Contact tracing
Coronaviruses
COVID-19
COVID-19 - epidemiology
COVID-19 - transmission
COVID-19 Serological Testing
Cross-Sectional Studies
Disease control
Disease transmission
Epidemics
Female
Fever
Humans
Infections
Iran - epidemiology
Male
Middle Aged
Original Paper
Polls & surveys
Population
Public health
Recall
Seroepidemiologic Studies
Seroepidemiology
Severe acute respiratory syndrome coronavirus 2
Signs and symptoms
Social distancing
Viral diseases
Young Adult
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Summary:The prevalence of asymptomatic infection by coronavirus disease 2019 (COVID-19) as a critical measure for effectiveness of mitigation strategy has been reported to be widely varied. In this study, we aimed to determine the prevalence of asymptomatic infection using serosurvey on general population. In a cross-sectional seroprevalence survey in Guilan province, Iran, the specific antibody against COVID-19 in a representative sample was detected using rapid test kits. Among 117 seropositive subjects, prevalence of asymptomatic infection was determined based on the history of symptoms during the preceding 3 months. The design-adjusted prevalence of asymptomatic infection was 57.2% (95% confidence interval (CI) 44–69). The prevalence was significantly lower in subjects with previous contacts to COVID-19 patients (12%, 95% CI 2–49) than others without (69%, 95% CI, 46–86). The lowest prevalence was for painful body symptom (74.4%). This study revealed that more than half of the infected COVID-19 patients had no symptoms. The implications of our findings include the importance of adopting public health measures such as social distancing and inefficiency of contact tracing to interrupt epidemic transmission.
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268820002745