Comparison of the effects of 1/10,000 and 1/100,000 concentrations of intracameral epinephrine on corneal endothelium and macular thickness after uncomplicated phacoemulsification

Purpose To evaluate the changes in the corneal endothelial cell parameters and macular thickness after intraocular application of epinephrine 1 10 , 000 and epinephrine 1 100 , 000 . Methods In this study, 210 eyes from 210 patients with age-related cataracts who underwent uncomplicated surgery were...

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Bibliographic Details
Published in:Eye (London) 2020-12, Vol.34 (12), p.2300-2306
Main Authors: Bamdad, Shahram, Khalili, Mohammad Reza, Rahimi, Reza
Format: Article
Language:English
Subjects:
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Age
Cataracts
Cell density
Cornea
Endothelial cells
Endothelium
Epinephrine
Laboratory Medicine
Medicine
Medicine & Public Health
Microscopy
Ophthalmology
Pharmaceutical Sciences/Technology
Statistical analysis
Surgery
Surgical Oncology
Toxicity
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Summary:Purpose To evaluate the changes in the corneal endothelial cell parameters and macular thickness after intraocular application of epinephrine 1 10 , 000 and epinephrine 1 100 , 000 . Methods In this study, 210 eyes from 210 patients with age-related cataracts who underwent uncomplicated surgery were included. For all patients, specular microscopy of the corneal endothelium and macular OCT were performed before surgery and 3 months after the surgery. Patients were divided randomly into three groups: without drug (control group), epinephrine 1 10 , 000 , and epinephrine 1 100 , 000 . Three months after the surgery, specular microscopy of the cornea and macular OCT measurements were performed. Measurements were compared between the three groups. Postoperative measurements were also compared with those measurements obtained before surgery. Results All the three groups showed a statistically significant decrease in the endothelial cell density after surgery; the reduction in endothelial cell density in the epinephrine 1 10 , 000 group was significantly more than those of the other two groups ( P value 
ISSN:0950-222X
1476-5454
DOI:10.1038/s41433-020-0812-5