Modulation of cholinergic activity through lynx prototoxins: Implications for cognition and anxiety regulation

[Display omitted] •Cholinergic signaling is broad due to widespread cholinergic axonal radiation.•Prototoxins exert spatial selectivity by binding to specific nAChR subtypes.•Different prototoxins up- and down-regulate nAChR function.•Cell-type specific prototoxins effect nuanced circuit responses t...

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Bibliographic Details
Published in:Neuropharmacology 2020-09, Vol.174, p.108071-108071, Article 108071
Main Authors: Anderson, Kristin R., Hoffman, Katie M., Miwa, Julie M.
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - chemistry
Adaptor Proteins, Signal Transducing - metabolism
Adaptor Proteins, Signal Transducing - therapeutic use
Animals
Anxiety - drug therapy
Anxiety - metabolism
Anxiety - psychology
Cholinergic Agents - chemistry
Cholinergic Agents - metabolism
Cholinergic Agents - therapeutic use
Cholinergic Neurons - drug effects
Cholinergic Neurons - metabolism
Cognition - drug effects
Cognition - physiology
Humans
Nicotinic Agonists - chemistry
Nicotinic Agonists - metabolism
Nicotinic Agonists - therapeutic use
Nicotinic Antagonists - chemistry
Nicotinic Antagonists - metabolism
Nicotinic Antagonists - therapeutic use
Protein Structure, Secondary
Receptors, Nicotinic - chemistry
Receptors, Nicotinic - metabolism
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Summary:[Display omitted] •Cholinergic signaling is broad due to widespread cholinergic axonal radiation.•Prototoxins exert spatial selectivity by binding to specific nAChR subtypes.•Different prototoxins up- and down-regulate nAChR function.•Cell-type specific prototoxins effect nuanced circuit responses to acetylcholine.•Circuit modulation alters plasticity, learning, anxiety, etc.
ISSN:0028-3908
1873-7064
1873-7064
DOI:10.1016/j.neuropharm.2020.108071