MEG Theta during Lexico-Semantic and Executive Processing Is Altered in High-Functioning Adolescents with Autism

• Published in: Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2021-01, Vol.31 (2), p.1116-1130
• Main Authors: You, Yuqi, Correas, Angeles, Jao Keehn, R Joanne, Wagner, Laura C, Rosen, Burke Q, Beaton, Lauren E, Gao, Yangfeifei, Brocklehurst, William T, Fishman, Inna, Müller, Ralph-Axel, Marinkovic, Ksenija
• Format: Article
• Language: English
• Subjects: Adolescent; Autism Spectrum Disorder - diagnostic imaging; Autism Spectrum Disorder - physiopathology; Autism Spectrum Disorder - psychology; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - physiology; Child; Executive Function - physiology; Female; Humans; Magnetic Resonance Imaging - methods; Magnetoencephalography - methods; Male; Original; Psychomotor Performance - physiology; Reaction Time - physiology; Semantics; Theta Rhythm - physiology; Young Adult
• ISSN: 1047-3211; 1460-2199
• DOI: 10.1093/cercor/bhaa279

Abstract Neuroimaging studies have revealed atypical activation during language and executive tasks in individuals with autism spectrum disorders (ASD). However, the spatiotemporal stages of processing associated with these dysfunctions remain poorly understood. Using an anatomically constrained magnetoencephalography approach, we examined event-related theta oscillations during a double-duty lexical decision task that combined demands on lexico-semantic processing and executive functions. Relative to typically developing peers, high-functioning adolescents with ASD had lower performance accuracy on trials engaging selective semantic retrieval and cognitive control. They showed an early overall theta increase in the left fusiform cortex followed by greater activity in the left-lateralized temporal (starting at ~250 ms) and frontal cortical areas (after ~450 ms) known to contribute to language processing. During response preparation and execution, the ASD group exhibited elevated theta in the anterior cingulate cortex, indicative of greater engagement of cognitive control. Simultaneously increased activity in the ipsilateral motor cortex may reflect a less lateralized and suboptimally organized motor circuitry. Spanning early sensory-specific and late response selection stages, the higher event-related theta responsivity in ASD may indicate compensatory recruitment to offset inefficient lexico-semantic retrieval under cognitively demanding conditions. Together, these findings provide further support for atypical language and executive functions in high-functioning ASD.