Potential Role of Zinc in the COVID-19 Disease Process and its Probable Impact on Reproduction

COVID-19 (coronavirus disease 2019) is the current world health crisis, producing extensive morbidity and mortality across all age groups. Given the established roles of zinc in combating oxidative damage and viral infections, zinc is being trialed as a treatment modality against COVID-19. Zinc also...

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Bibliographic Details
Published in:Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2022-01, Vol.29 (1), p.1-6
Main Authors: Sethuram, Ramya, Bai, David, Abu-Soud, Husam M.
Format: Article
Language:English
Subjects:
COVID-19 - metabolism
Embryology
Female
Humans
Male
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Oxidative Stress - physiology
Reactive Oxygen Species - metabolism
Reproduction - physiology
Reproductive Medicine
Review
Zinc - metabolism
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Summary:COVID-19 (coronavirus disease 2019) is the current world health crisis, producing extensive morbidity and mortality across all age groups. Given the established roles of zinc in combating oxidative damage and viral infections, zinc is being trialed as a treatment modality against COVID-19. Zinc also has confirmed roles in both male and female reproduction. The possible depletion of zinc with the oxidative events of COVID-19 is especially relevant to the fertility of affected couples. This review aims to present the pathophysiology of COVID-19, especially in relation to reproductive function; the role of zinc in the COVID-19 disease process; and how zinc depletion in concert with cytokine storm and reactive oxygen species production could affect reproduction. It also highlights research areas to better the understanding of COVID-19 and its impact on fertility and potential ways to mitigate the impact.
ISSN:1933-7191
1933-7205
DOI:10.1007/s43032-020-00400-6