miR-205 in Breast Cancer: State of the Art

Despite its controversial roles in different cancer types, miR-205 has been mainly described as an oncosuppressive microRNA (miRNA), with some contrasting results, in breast cancer. The role of miR-205 in the occurrence or progression of breast cancer has been extensively studied since the first evi...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-12, Vol.22 (1), p.27
Main Authors: Plantamura, Ilaria, Cataldo, Alessandra, Cosentino, Giulia, Iorio, Marilena V
Format: Article
Language:English
Subjects:
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Breast Neoplasms - therapy
Cell Proliferation - genetics
Disease Progression
Epithelial-Mesenchymal Transition - genetics
Female
Gene Expression Profiling - methods
Gene Expression Regulation, Neoplastic
Humans
MicroRNAs - genetics
Review
Tumor Microenvironment - genetics
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Summary:Despite its controversial roles in different cancer types, miR-205 has been mainly described as an oncosuppressive microRNA (miRNA), with some contrasting results, in breast cancer. The role of miR-205 in the occurrence or progression of breast cancer has been extensively studied since the first evidence of its aberrant expression in tumor tissues versus normal counterparts. To date, it is known that the expression of miR-205 in the different subtypes of breast cancer is decreasing from the less aggressive subtype, estrogen receptor/progesterone receptor positive breast cancer, to the more aggressive, triple negative breast cancer, influencing metastasis capability, response to therapy and patient survival. In this review, we summarize the most important discoveries that have highlighted the functional role of this miRNA in breast cancer initiation and progression, in stemness maintenance, in the tumor microenvironment, its potential role as a biomarker and its relevance in normal breast physiology-the still open questions. Finally, emerging evidence reveals the role of some lncRNAs in breast cancer progression as sponges of miR-205. Here, we also reviewed the studies in this field.
ISSN:1422-0067
1422-0067
DOI:10.3390/ijms22010027