Radon Exposure-Therapeutic Effect and Cancer Risk

Largely unnoticed, all life on earth is constantly exposed to low levels of ionizing radiation. Radon, an imperceptible natural occurring radioactive noble gas, contributes as the largest single fraction to radiation exposure from natural sources. For that reason, radon represents a major issue for...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2020-12, Vol.22 (1), p.316
Main Authors: Maier, Andreas, Wiedemann, Julia, Rapp, Felicitas, Papenfuß, Franziska, Rödel, Franz, Hehlgans, Stephanie, Gaipl, Udo S, Kraft, Gerhard, Fournier, Claudia, Frey, Benjamin
Format: Article
Language:English
Subjects:
Aerosols
Air Pollution, Indoor - adverse effects
Animals
Cancer
Chronic exposure
Clinical Trials as Topic
Degenerative diseases
Environmental Exposure - adverse effects
Gases
Humans
Ionizing radiation
Natural gas
Neoplasms - epidemiology
Neoplasms - etiology
Physiology
Progeny
Radiation effects
Radiation Exposure - adverse effects
Radiation Monitoring
Radiation protection
Radioactive decay
Radon
Radon - adverse effects
Radon - therapeutic use
Regions
Review
Risk Assessment
Risk Factors
Simulation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c478t-417407853b6192a63e920668672423b784bd00cada93246001b3bf35cf697ed53
cites cdi_FETCH-LOGICAL-c478t-417407853b6192a63e920668672423b784bd00cada93246001b3bf35cf697ed53
container_end_page
container_issue 1
container_start_page 316
container_title International journal of molecular sciences
container_volume 22
creator Maier, Andreas
Wiedemann, Julia
Rapp, Felicitas
Papenfuß, Franziska
Rödel, Franz
Hehlgans, Stephanie
Gaipl, Udo S
Kraft, Gerhard
Fournier, Claudia
Frey, Benjamin
description Largely unnoticed, all life on earth is constantly exposed to low levels of ionizing radiation. Radon, an imperceptible natural occurring radioactive noble gas, contributes as the largest single fraction to radiation exposure from natural sources. For that reason, radon represents a major issue for radiation protection. Nevertheless, radon is also applied for the therapy of inflammatory and degenerative diseases in galleries and spas to many thousand patients a year. In either case, chronic environmental exposure or therapy, the effect of radon on the organism exposed is still under investigation at all levels of interaction. This includes the physical stage of diffusion and energy deposition by radioactive decay of radon and its progeny and the biological stage of initiating and propagating a physiologic response or inducing cancer after chronic exposure. The purpose of this manuscript is to comprehensively review the current knowledge of radon and its progeny on physical background, associated cancer risk and potential therapeutic effects.
doi_str_mv 10.3390/ijms22010316
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7796069</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2475006884</sourcerecordid><originalsourceid>FETCH-LOGICAL-c478t-417407853b6192a63e920668672423b784bd00cada93246001b3bf35cf697ed53</originalsourceid><addsrcrecordid>eNpVkMtLw0AQhxdRbK3ePEvAq9HZR_ZxEaTUBxSEUs_LZrOxqW027iZF_3sjraWeZmC--c3wIXSJ4ZZSBXfVch0JAQwU8yM0xIyQFICL44N-gM5iXAIQSjJ1iga03-QSZ0OEZ6bwdTL5anzsgkvnCxdM47q2ssmkLJ1tE1MXydjU1oVkVsWPc3RSmlV0F7s6Qm-Pk_n4OZ2-Pr2MH6apZUK2KcOCgZAZzTlWxHDqFAHOJReEEZoLyfICwJrCKEoYB8A5zUua2ZIr4YqMjtD9Nrfp8rUrrKvbYFa6CdXahG_tTaX_T-pqod_9RguhOHDVB1zvAoL_7Fxs9dJ3oe5_1oSJrPciJeupmy1lg48xuHJ_AYP-FawPBff41eFXe_jPKP0BqRR02w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2475006884</pqid></control><display><type>article</type><title>Radon Exposure-Therapeutic Effect and Cancer Risk</title><source>Open Access: PubMed Central</source><source>Publicly Available Content Database</source><creator>Maier, Andreas ; Wiedemann, Julia ; Rapp, Felicitas ; Papenfuß, Franziska ; Rödel, Franz ; Hehlgans, Stephanie ; Gaipl, Udo S ; Kraft, Gerhard ; Fournier, Claudia ; Frey, Benjamin</creator><creatorcontrib>Maier, Andreas ; Wiedemann, Julia ; Rapp, Felicitas ; Papenfuß, Franziska ; Rödel, Franz ; Hehlgans, Stephanie ; Gaipl, Udo S ; Kraft, Gerhard ; Fournier, Claudia ; Frey, Benjamin</creatorcontrib><description>Largely unnoticed, all life on earth is constantly exposed to low levels of ionizing radiation. Radon, an imperceptible natural occurring radioactive noble gas, contributes as the largest single fraction to radiation exposure from natural sources. For that reason, radon represents a major issue for radiation protection. Nevertheless, radon is also applied for the therapy of inflammatory and degenerative diseases in galleries and spas to many thousand patients a year. In either case, chronic environmental exposure or therapy, the effect of radon on the organism exposed is still under investigation at all levels of interaction. This includes the physical stage of diffusion and energy deposition by radioactive decay of radon and its progeny and the biological stage of initiating and propagating a physiologic response or inducing cancer after chronic exposure. The purpose of this manuscript is to comprehensively review the current knowledge of radon and its progeny on physical background, associated cancer risk and potential therapeutic effects.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms22010316</identifier><identifier>PMID: 33396815</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Aerosols ; Air Pollution, Indoor - adverse effects ; Animals ; Cancer ; Chronic exposure ; Clinical Trials as Topic ; Degenerative diseases ; Environmental Exposure - adverse effects ; Gases ; Humans ; Ionizing radiation ; Natural gas ; Neoplasms - epidemiology ; Neoplasms - etiology ; Physiology ; Progeny ; Radiation effects ; Radiation Exposure - adverse effects ; Radiation Monitoring ; Radiation protection ; Radioactive decay ; Radon ; Radon - adverse effects ; Radon - therapeutic use ; Regions ; Review ; Risk Assessment ; Risk Factors ; Simulation</subject><ispartof>International journal of molecular sciences, 2020-12, Vol.22 (1), p.316</ispartof><rights>2021. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-417407853b6192a63e920668672423b784bd00cada93246001b3bf35cf697ed53</citedby><cites>FETCH-LOGICAL-c478t-417407853b6192a63e920668672423b784bd00cada93246001b3bf35cf697ed53</cites><orcidid>0000-0001-6743-3351 ; 0000-0001-6375-5476 ; 0000-0003-1309-5435 ; 0000-0002-6816-3450 ; 0000-0003-0968-1546</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2475006884/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2475006884?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,44589,53790,53792,74897</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33396815$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maier, Andreas</creatorcontrib><creatorcontrib>Wiedemann, Julia</creatorcontrib><creatorcontrib>Rapp, Felicitas</creatorcontrib><creatorcontrib>Papenfuß, Franziska</creatorcontrib><creatorcontrib>Rödel, Franz</creatorcontrib><creatorcontrib>Hehlgans, Stephanie</creatorcontrib><creatorcontrib>Gaipl, Udo S</creatorcontrib><creatorcontrib>Kraft, Gerhard</creatorcontrib><creatorcontrib>Fournier, Claudia</creatorcontrib><creatorcontrib>Frey, Benjamin</creatorcontrib><title>Radon Exposure-Therapeutic Effect and Cancer Risk</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Largely unnoticed, all life on earth is constantly exposed to low levels of ionizing radiation. Radon, an imperceptible natural occurring radioactive noble gas, contributes as the largest single fraction to radiation exposure from natural sources. For that reason, radon represents a major issue for radiation protection. Nevertheless, radon is also applied for the therapy of inflammatory and degenerative diseases in galleries and spas to many thousand patients a year. In either case, chronic environmental exposure or therapy, the effect of radon on the organism exposed is still under investigation at all levels of interaction. This includes the physical stage of diffusion and energy deposition by radioactive decay of radon and its progeny and the biological stage of initiating and propagating a physiologic response or inducing cancer after chronic exposure. The purpose of this manuscript is to comprehensively review the current knowledge of radon and its progeny on physical background, associated cancer risk and potential therapeutic effects.</description><subject>Aerosols</subject><subject>Air Pollution, Indoor - adverse effects</subject><subject>Animals</subject><subject>Cancer</subject><subject>Chronic exposure</subject><subject>Clinical Trials as Topic</subject><subject>Degenerative diseases</subject><subject>Environmental Exposure - adverse effects</subject><subject>Gases</subject><subject>Humans</subject><subject>Ionizing radiation</subject><subject>Natural gas</subject><subject>Neoplasms - epidemiology</subject><subject>Neoplasms - etiology</subject><subject>Physiology</subject><subject>Progeny</subject><subject>Radiation effects</subject><subject>Radiation Exposure - adverse effects</subject><subject>Radiation Monitoring</subject><subject>Radiation protection</subject><subject>Radioactive decay</subject><subject>Radon</subject><subject>Radon - adverse effects</subject><subject>Radon - therapeutic use</subject><subject>Regions</subject><subject>Review</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Simulation</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpVkMtLw0AQhxdRbK3ePEvAq9HZR_ZxEaTUBxSEUs_LZrOxqW027iZF_3sjraWeZmC--c3wIXSJ4ZZSBXfVch0JAQwU8yM0xIyQFICL44N-gM5iXAIQSjJ1iga03-QSZ0OEZ6bwdTL5anzsgkvnCxdM47q2ssmkLJ1tE1MXydjU1oVkVsWPc3RSmlV0F7s6Qm-Pk_n4OZ2-Pr2MH6apZUK2KcOCgZAZzTlWxHDqFAHOJReEEZoLyfICwJrCKEoYB8A5zUua2ZIr4YqMjtD9Nrfp8rUrrKvbYFa6CdXahG_tTaX_T-pqod_9RguhOHDVB1zvAoL_7Fxs9dJ3oe5_1oSJrPciJeupmy1lg48xuHJ_AYP-FawPBff41eFXe_jPKP0BqRR02w</recordid><startdate>20201230</startdate><enddate>20201230</enddate><creator>Maier, Andreas</creator><creator>Wiedemann, Julia</creator><creator>Rapp, Felicitas</creator><creator>Papenfuß, Franziska</creator><creator>Rödel, Franz</creator><creator>Hehlgans, Stephanie</creator><creator>Gaipl, Udo S</creator><creator>Kraft, Gerhard</creator><creator>Fournier, Claudia</creator><creator>Frey, Benjamin</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6743-3351</orcidid><orcidid>https://orcid.org/0000-0001-6375-5476</orcidid><orcidid>https://orcid.org/0000-0003-1309-5435</orcidid><orcidid>https://orcid.org/0000-0002-6816-3450</orcidid><orcidid>https://orcid.org/0000-0003-0968-1546</orcidid></search><sort><creationdate>20201230</creationdate><title>Radon Exposure-Therapeutic Effect and Cancer Risk</title><author>Maier, Andreas ; Wiedemann, Julia ; Rapp, Felicitas ; Papenfuß, Franziska ; Rödel, Franz ; Hehlgans, Stephanie ; Gaipl, Udo S ; Kraft, Gerhard ; Fournier, Claudia ; Frey, Benjamin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-417407853b6192a63e920668672423b784bd00cada93246001b3bf35cf697ed53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aerosols</topic><topic>Air Pollution, Indoor - adverse effects</topic><topic>Animals</topic><topic>Cancer</topic><topic>Chronic exposure</topic><topic>Clinical Trials as Topic</topic><topic>Degenerative diseases</topic><topic>Environmental Exposure - adverse effects</topic><topic>Gases</topic><topic>Humans</topic><topic>Ionizing radiation</topic><topic>Natural gas</topic><topic>Neoplasms - epidemiology</topic><topic>Neoplasms - etiology</topic><topic>Physiology</topic><topic>Progeny</topic><topic>Radiation effects</topic><topic>Radiation Exposure - adverse effects</topic><topic>Radiation Monitoring</topic><topic>Radiation protection</topic><topic>Radioactive decay</topic><topic>Radon</topic><topic>Radon - adverse effects</topic><topic>Radon - therapeutic use</topic><topic>Regions</topic><topic>Review</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Simulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maier, Andreas</creatorcontrib><creatorcontrib>Wiedemann, Julia</creatorcontrib><creatorcontrib>Rapp, Felicitas</creatorcontrib><creatorcontrib>Papenfuß, Franziska</creatorcontrib><creatorcontrib>Rödel, Franz</creatorcontrib><creatorcontrib>Hehlgans, Stephanie</creatorcontrib><creatorcontrib>Gaipl, Udo S</creatorcontrib><creatorcontrib>Kraft, Gerhard</creatorcontrib><creatorcontrib>Fournier, Claudia</creatorcontrib><creatorcontrib>Frey, Benjamin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maier, Andreas</au><au>Wiedemann, Julia</au><au>Rapp, Felicitas</au><au>Papenfuß, Franziska</au><au>Rödel, Franz</au><au>Hehlgans, Stephanie</au><au>Gaipl, Udo S</au><au>Kraft, Gerhard</au><au>Fournier, Claudia</au><au>Frey, Benjamin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radon Exposure-Therapeutic Effect and Cancer Risk</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2020-12-30</date><risdate>2020</risdate><volume>22</volume><issue>1</issue><spage>316</spage><pages>316-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Largely unnoticed, all life on earth is constantly exposed to low levels of ionizing radiation. Radon, an imperceptible natural occurring radioactive noble gas, contributes as the largest single fraction to radiation exposure from natural sources. For that reason, radon represents a major issue for radiation protection. Nevertheless, radon is also applied for the therapy of inflammatory and degenerative diseases in galleries and spas to many thousand patients a year. In either case, chronic environmental exposure or therapy, the effect of radon on the organism exposed is still under investigation at all levels of interaction. This includes the physical stage of diffusion and energy deposition by radioactive decay of radon and its progeny and the biological stage of initiating and propagating a physiologic response or inducing cancer after chronic exposure. The purpose of this manuscript is to comprehensively review the current knowledge of radon and its progeny on physical background, associated cancer risk and potential therapeutic effects.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33396815</pmid><doi>10.3390/ijms22010316</doi><orcidid>https://orcid.org/0000-0001-6743-3351</orcidid><orcidid>https://orcid.org/0000-0001-6375-5476</orcidid><orcidid>https://orcid.org/0000-0003-1309-5435</orcidid><orcidid>https://orcid.org/0000-0002-6816-3450</orcidid><orcidid>https://orcid.org/0000-0003-0968-1546</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1422-0067
ispartof International journal of molecular sciences, 2020-12, Vol.22 (1), p.316
issn 1422-0067
1661-6596
1422-0067
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7796069
source Open Access: PubMed Central; Publicly Available Content Database
subjects Aerosols
Air Pollution, Indoor - adverse effects
Animals
Cancer
Chronic exposure
Clinical Trials as Topic
Degenerative diseases
Environmental Exposure - adverse effects
Gases
Humans
Ionizing radiation
Natural gas
Neoplasms - epidemiology
Neoplasms - etiology
Physiology
Progeny
Radiation effects
Radiation Exposure - adverse effects
Radiation Monitoring
Radiation protection
Radioactive decay
Radon
Radon - adverse effects
Radon - therapeutic use
Regions
Review
Risk Assessment
Risk Factors
Simulation
title Radon Exposure-Therapeutic Effect and Cancer Risk
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T22%3A47%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Radon%20Exposure-Therapeutic%20Effect%20and%20Cancer%20Risk&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Maier,%20Andreas&rft.date=2020-12-30&rft.volume=22&rft.issue=1&rft.spage=316&rft.pages=316-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms22010316&rft_dat=%3Cproquest_pubme%3E2475006884%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c478t-417407853b6192a63e920668672423b784bd00cada93246001b3bf35cf697ed53%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2475006884&rft_id=info:pmid/33396815&rfr_iscdi=true