The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and Activity

The hypoxia signalling pathway enables adaptation of cells to decreased oxygen availability. When oxygen becomes limiting, the central transcription factors of the pathway, hypoxia-inducible factors (HIFs), are stabilised and activated to induce the expression of hypoxia-regulated genes, thereby mai...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-12, Vol.22 (1), p.268
Main Authors: Albanese, Adam, Daly, Leonard A, Mennerich, Daniela, Kietzmann, Thomas, Sée, Violaine
Format: Article
Language:English
Subjects:
Animals
Basic Helix-Loop-Helix Transcription Factors - genetics
Basic Helix-Loop-Helix Transcription Factors - metabolism
Biomarkers
Cell cycle
Enzymes
Evolutionary conservation
Gene expression
Genes
Homeostasis
Humans
Hydroxylation
Hypoxia
Hypoxia - genetics
Hypoxia - metabolism
Hypoxia-Inducible Factor 1, alpha Subunit - genetics
Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
Hypoxia-inducible factors
Kinases
Life Sciences
Localization
Mammals
Phosphorylation
Post-translation
Protein Processing, Post-Translational
Protein Stability
Protein Transport
Proteins
Regulation
Review
Roles
Signal Transduction
Stability
Transcription factors
Translation
Ubiquitination
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Summary:The hypoxia signalling pathway enables adaptation of cells to decreased oxygen availability. When oxygen becomes limiting, the central transcription factors of the pathway, hypoxia-inducible factors (HIFs), are stabilised and activated to induce the expression of hypoxia-regulated genes, thereby maintaining cellular homeostasis. Whilst hydroxylation has been thoroughly described as the major and canonical modification of the HIF-α subunits, regulating both HIF stability and activity, a range of other post-translational modifications decorating the entire protein play also a crucial role in altering HIF localisation, stability, and activity. These modifications, their conservation throughout evolution, and their effects on HIF-dependent signalling are discussed in this review.
ISSN:1422-0067
1661-6596
1422-0067
1661-6596
DOI:10.3390/ijms22010268