Spectrum of cardiovascular diseases in children during high peak COVID-19 period infection in Northern Italy: is there a link?

Children with COVID-19 have a milder clinical course than adults. We describe the spectrum of cardiovascular manifestations during a COVID-19 outbreak in Emilia-Romagna, Italy. Cross-sectional multicenter study including all diagnosis of KD, myocarditis and multisystem inflammatory syndrome in child...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the Pediatric Infectious Diseases Society 2020-12
Main Authors: Fabi, Marianna, Filice, Emanuele, Andreozzi, Laura, Conti, Francesca, Gabrielli, Liliana, Balducci, Anna, Vergine, Gianluca, Cicero Md, Cristina, Iughetti, Lorenzo, Guerzoni, Maria Elena, Corinaldesi, Elena, Lazzarotto, Tiziana, Pession, Andrea, Lanari, Marcello
Format: Article
Language:English
Subjects:
Original
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Children with COVID-19 have a milder clinical course than adults. We describe the spectrum of cardiovascular manifestations during a COVID-19 outbreak in Emilia-Romagna, Italy. Cross-sectional multicenter study including all diagnosis of KD, myocarditis and multisystem inflammatory syndrome in children (MIS-C) from February to April,2020. KD patients were compared to those diagnosed before the epidemic. KD: 8 patients (6/8 boys, all negative for SARS-CoV-2); complete presentation in 5/8; 7/8 IVIG-responders; 3/8 showed transient coronary lesions (CALs). one 5-year-old girl negative for SARS-CoV-2, positive for Parvovirus B19. She responded to IVIG. 4 SARS-CoV-2 positive boys (3 patients with positive swab and serology, 1 patient with negative swab and positive serology). Three presented myocardial dysfunction and pericardial effusion, one developed multicoronary aneurysms and hyperinflammation; all responded to treatment. The fourth boy had mitral and aortic regurgitation that rapidly regressed after steroids. KD, myocarditis and MIS-C were distinguishable cardiovascular manifestations. KD did not show a more aggressive form compared to previous years: coronary involvement was frequent, but always transient. MIS-C and myocarditis rapidly responded to treatment without cardiac sequelae despite high markers of myocardial injury at onset suggesting a myocardial depression due to systemic inflammation rather than focal necrosis. Evidence of actual or previous SARS-CoV-2 infection was documented only in patients with MIS-C.
ISSN:2048-7193
2048-7207
DOI:10.1093/jpids/piaa162