Premature Onset Aortic Stenosis in Systemic Sclerosis: A Report of a Series of Cases

• Published in: Internal Medicine 2020/12/15, Vol.59(24), pp.3177-3181
• Main Authors: Machida, Ayaka, Funaki, Takashi, Nishida, Koji, Imai, Ryu-ichiro, Nakaoka, Yoko, Seki, Shu-ichi, Baba, Yu-ichi, Kubo, Toru, Yamasaki, Naohito, Kitaoka, Hiroaki, Kubokawa, Sho-ichi, Sakaeda, Hiroshi, Kawai, Kazuya, Hamashige, Naohisa, Doi, Yoshinori
• Format: Article
• Language: English
• Subjects: Aged; aging society; Aortic stenosis; Aortic valve; Aortic Valve - surgery; Aortic Valve Stenosis - diagnostic imaging; Aortic Valve Stenosis - surgery; Cardiovascular disease; Case Report; clinical frailty scale; Coronary artery disease; elderly patient; Frail Elderly; Heart diseases; Humans; Internal medicine; premature onset aortic stenosis; Retrospective Studies; Rheumatic heart disease; Risk Factors; Scleroderma; Scleroderma, Systemic - complications; Stenosis; Systemic sclerosis; transcatheter aortic valve replacement; Transcatheter Aortic Valve Replacement - adverse effects; Treatment Outcome
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.5226-20

Although cardiovascular involvement is a well-known complication correlated with a poor prognosis in patients with systemic sclerosis, there are few reports on valvular heart disease. Forty patients with systemic sclerosis were retrospectively analyzed. Valvular heart disease was found in six patients, five of whom had severe tri-leaflet aortic stenosis. Three of these 5 patients were ≤71 years old. Two frail elderly patients who underwent transcatheter aortic valve replacement died within two years. Premature-onset aortic stenosis is not uncommon in patients with systemic sclerosis. When considering mechanical intervention, the evaluation of frailty is important.