Molecular Biological Features of Nottingham Histological Grade 3 Breast Cancers

Introduction Cancer biology dominates the behavior and prognosis of a tumor. Although Nottingham histological grade is a subjective pathological determination, it has been accepted as a surrogate model for cancer biology. As such, histologic grade was incorporated into the latest 8th edition of the...

Full description

Saved in:
Bibliographic Details
Published in:Annals of surgical oncology 2020-10, Vol.27 (11), p.4475-4485
Main Authors: Takahashi, Hideo, Oshi, Masanori, Asaoka, Mariko, Yan, Li, Endo, Itaru, Takabe, Kazuaki
Format: Article
Language:English
Subjects:
Biology
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - immunology
Breast Neoplasms - pathology
Breast Oncology
Cell cycle
Cell proliferation
Cytolytic activity
Epidermal growth factor
Estrogen receptors
Female
Gene set enrichment analysis
Genomes
Humans
Immunogenicity
Ki-67 Antigen - metabolism
Lymphocytes T
Macrophages
Medical prognosis
Medicine
Medicine & Public Health
Natural killer cells
Neoplasm Grading
Neoplasm Staging
Oncology
Prognosis
Receptor, ErbB-2 - metabolism
Surgery
Surgical Oncology
T cell receptors
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction Cancer biology dominates the behavior and prognosis of a tumor. Although Nottingham histological grade is a subjective pathological determination, it has been accepted as a surrogate model for cancer biology. As such, histologic grade was incorporated into the latest 8th edition of the American Joint Committee on Cancer breast cancer staging system. In this study, we hypothesized that grade 3 breast cancers demonstrate aggressive molecular biological profiles, reflecting worse biology and possible underlying immunogenicity. Methods Transcriptomic and clinical data were obtained from the Molecular Taxonomy of Breast Cancer International Consortium, and the findings were validated by The Cancer Genome Atlas breast cancer cohort and GSE25066. Results Overall, 2876 patients were analyzed in this study. Grade 3 tumors were more common in estrogen receptor (ER)-negative, advanced-stage patients, and were associated with human epidermal growth factor receptor 2 and basal subtypes by the PAM50 classifier, as well as with increased MKI67 expression (all p 
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-020-08608-1