The Effect of Exercise During Pregnancy on Maternal and Offspring Vascular Outcomes: a Pilot Study

• Published in: Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2021-02, Vol.28 (2), p.510-523
• Main Authors: Brislane, Áine, Jones, Helen, Holder, Sophie M., Low, David A., Hopkins, Nicola D.
• Format: Article
• Language: English
• Subjects: Developmental Programming: Original; Developmental Programming: Original Article; Embryology; Medicine; Medicine & Public Health; Obstetrics/Perinatology/Midwifery; Reproductive Medicine
• ISSN: 1933-7191; 1933-7205
• DOI: 10.1007/s43032-020-00302-7

The aim of this pilot study is to obtain estimates for the change in maternal cerebrovascular (primary) and offspring vascular structure (secondary) during healthy pregnancy that includes structured exercise. Eighteen pregnant women self-assigned to a moderate-intensity aerobic exercise intervention or a control group. Maternal cerebral blood flow (CBF) at the middle cerebral artery, cerebro- and peripheral-vascular function was assessed at the end of each trimester. Offspring carotid artery intima-media thickness (IMT) was measured within 12 weeks of birth. For exploratory purposes, we performed statistical analysis to provide estimates of the change for primary and secondary outcome variables. Maternal CBF reduced (− 8 cm s −1 [− 14 to − 2]) with evidence of change to cerebral autoregulation (normalised gain: 0.12 %cm s −1 % mmHg −1 mmHg/% [− 0.18 to 0.40]) during pregnancy. Offspring carotid IMT was smaller in the exercise group (− 0.04 mm [− 0.12–0.03]) compared with controls. Based upon this data, a sample size of 33 and 57 in each group is required for low-frequency normalised gain and offspring IMT, respectively. This would provide 90% power to detect statistically significant ( P