Momordica cymbalaria improves reproductive parameters in alloxan-induced male diabetic rats

Male reproductive dysfunction is one of the common complications of diabetes mellitus that causes infertility. This study was designed to investigate the protective effect of Momordica cymbalaria ( M. cymbalaria ) extracts on diabetes mediated reproductive toxicity in male Wistar rats. The induction...

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Bibliographic Details
Published in:3 Biotech 2021-02, Vol.11 (2), p.76, Article 76
Main Authors: Elangovan, Abbirami, Durairaj, Siva, Subramanian, Abinaya, Ramakrishnan, Sooraj, Lakshmanan, Dinesh Kumar, Ravichandran, Guna, Thilagar, Sivasudha
Format: Article
Language:English
Subjects:
Agriculture
Alloxan
Antidiabetics
Antioxidants
Bioinformatics
Biomaterials
Biotechnology
Blood
Blood glucose
Cancer Research
Chemistry
Chemistry and Materials Science
Diabetes
Diabetes mellitus
Glucose
Glutathione
Glutathione transferase
Infertility
Malondialdehyde
Momordica
Oral administration
Original
Original Article
Parameters
Reproductive health
Reproductive organs
Reproductive system
Rodents
Sperm
Stem Cells
Superoxide dismutase
Testosterone
Toxicity
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Summary:Male reproductive dysfunction is one of the common complications of diabetes mellitus that causes infertility. This study was designed to investigate the protective effect of Momordica cymbalaria ( M. cymbalaria ) extracts on diabetes mediated reproductive toxicity in male Wistar rats. The induction of diabetes was performed using a single intraperitoneal injection of alloxan (120 mg/kg). Skin and seed extracts (250 and 500 mg/kg) of M. cymbalaria were orally administered to alloxan-induced diabetic male rats for 28 days. Postprandial blood glucose (PBG) levels were recorded at 7-day interval for four weeks. The effects of the treatment on blood glucose, weight of reproductive organs, sperm count, testosterone levels, antioxidant capacity, and histomorphology were evaluated. Treatment with the above extracts of M. cymbalaria significantly ( p  
ISSN:2190-572X
2190-5738
DOI:10.1007/s13205-020-02612-8