Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement

Abstract We describe a case of limb-threatening osteomyelitis and metalware infection with carbapenemase-producing extensively drug-resistant Pseudomonas aeruginosa successfully cured with aggressive surgical debridement and combined intravenous fosfomycin and colistin. Real-time therapeutic drug mo...

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Bibliographic Details
Published in:Open forum infectious diseases 2021-01, Vol.8 (1), p.ofaa572
Main Authors: Narayanasamy, Shanti, Nation, Roger L, Mahony, Andrew A, Grayson, M Lindsay, Kwong, Jason C, Sherry, Norelle L, Khumra, Sharmila, Ellis, Andrew G, Frauman, Albert G, Holmes, Natasha E
Format: Article
Language:English
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Novel ID Cases
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Summary:Abstract We describe a case of limb-threatening osteomyelitis and metalware infection with carbapenemase-producing extensively drug-resistant Pseudomonas aeruginosa successfully cured with aggressive surgical debridement and combined intravenous fosfomycin and colistin. Real-time therapeutic drug monitoring was used to maximize probability of efficacy and minimize potential for toxicity.
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofaa572