Let-7i-5p functions as a putative osteogenic differentiation promoter by targeting CKIP-1

MicroRNA (miRNA) is an endogenous regulatory small molecule RNA. Growing evidence shows that miRNA plays an important regulatory role in gene expression. Although miRNA is a more intensive regulatory noncoding RNA in recent years, few studies have investigated the regulation of targeting genes invol...

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Bibliographic Details
Published in:Cytotechnology (Dordrecht) 2021-02, Vol.73 (1), p.79-90
Main Authors: Zhang, Yang, Cheng, Wei, Han, Biao, Guo, Yong, Wei, Shuping, Yu, Lu, Zhang, Xizheng
Format: Article
Language:English
Subjects:
Biochemistry
Biomedicine
Biotechnology
Bone growth
Bone healing
Casein
Casein kinase II
Chemistry
Chemistry and Materials Science
Fractures
Gene expression
Gene regulation
Genes
Kinases
Laboratory animals
MicroRNAs
miRNA
Original
Original Article
Osteogenesis
Proteins
Regeneration
Signal transduction
Transcription factors
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Summary:MicroRNA (miRNA) is an endogenous regulatory small molecule RNA. Growing evidence shows that miRNA plays an important regulatory role in gene expression. Although miRNA is a more intensive regulatory noncoding RNA in recent years, few studies have investigated the regulation of targeting genes involved in bone repair. Meanwhile, as a negative bone regulator, previous studies showed that casein kinase 2-interacting protein 1 (CKIP-1) is closely associated with bone formation and regeneration. However, the gene knockout method may not be suitable for clinical application. Therefore, it was hypothesized that miRNA molecules can inhibit the expression of CKIP-1 and ultimately promote the osteogenesis process. The present study revealed that let-7i-5p plays an important role in the process of fracture healing by inhibiting the expression of CKIP-1. Related research provides a novel gene target for fracture healing.
ISSN:0920-9069
1573-0778
DOI:10.1007/s10616-020-00444-1