Gut Microbiota Features on Nursing Home Admission Are Associated With Subsequent Acquisition of Antibiotic-resistant Organism Colonization

Abstract Nursing home (NH) patients often acquire colonization with antibiotic-resistant organisms (AROs). We show that patients exposed to broad-spectrum antibiotics during previous hospitalizations have elevated enterococcal relative abundances on NH admission and higher risk of subsequent ARO acq...

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Bibliographic Details
Published in:Clinical infectious diseases 2020-12, Vol.71 (12), p.3244-3247
Main Authors: Wang, Joyce, Cassone, Marco, Gibson, Kristen, Lansing, Bonnie, Mody, Lona, Snitkin, Evan S, Rao, Krishna
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Brief Reports
Gastrointestinal Microbiome
Hospitalization
Humans
Nursing Homes
Skilled Nursing Facilities
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Summary:Abstract Nursing home (NH) patients often acquire colonization with antibiotic-resistant organisms (AROs). We show that patients exposed to broad-spectrum antibiotics during previous hospitalizations have elevated enterococcal relative abundances on NH admission and higher risk of subsequent ARO acquisition. Our findings suggest that interventions preventing ARO spread should extend beyond NH doors.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciaa662