A novel clinically-oriented classification of fine-needle aspiration cytology for salivary gland tumors: a 20-year retrospective analysis of 1175 patients

Background When determining treatment strategy for a salivary gland tumor, assessing histology and malignancy grade before surgery is essential. Several new diagnostic classification systems for salivary gland cytology have recently been proposed. However, none incorporate histology and grade of mal...

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Bibliographic Details
Published in:International journal of clinical oncology 2021-02, Vol.26 (2), p.326-334
Main Authors: Taniuchi, Masataka, Kawata, Ryo, Omura, Shuji, Haginomori, Shin- Ichi, Terada, Tetsuya, Higashino, Masaaki, Kurisu, Yoshitaka, Hirose, Yoshinobu
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biopsy, Fine-Needle
Cancer Research
Cellular biology
Child
Classification
Classification systems
Cytodiagnosis
Cytology
Diagnosis
Female
Histology
Humans
Male
Malignancy
Medicine
Medicine & Public Health
Middle Aged
Oncology
Oral cancer
Original
Original Article
Patients
Retrospective Studies
Salivary gland
Salivary Gland Neoplasms - classification
Salivary Gland Neoplasms - pathology
Salivary Glands - pathology
Surgery
Surgical Oncology
Tumors
Young Adult
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Summary:Background When determining treatment strategy for a salivary gland tumor, assessing histology and malignancy grade before surgery is essential. Several new diagnostic classification systems for salivary gland cytology have recently been proposed. However, none incorporate histology and grade of malignancy. Methods We developed a new cytology classification system that incorporates histology and grade of malignancy of salivary gland tumors (OMC classification), consisting of 11 categories. Our OMC classification was applied to 1175 patients who had preoperative cytology and confirmed final pathological diagnosis available from the past 20 years at our hospital (benign tumor: 981 patients, malignant tumor: 194 patients). Results Based on the cytology, 729 patients (62.0%) had benign histology (Category 4–1), and 87 patients (7.4%) were diagnosed with grade of malignancy (Category 6–3 + 6–4). Based on the final pathological diagnosis, the accuracy rate of Category 4–1 and Category 6–3 + 6–4 of our classification system was 93.4% and 88.5%, respectively. Conclusion Based on the correct diagnosis rate, the inclusion of histology and grade of malignancy in the salivary gland cytology classification was considered feasible. Thus, the OMC classification system is considered a useful tool when determining the treatment strategy for a salivary gland tumor.
ISSN:1341-9625
1437-7772
DOI:10.1007/s10147-020-01816-5