Factors associated with achieving target serum uric acid level and occurrence of gouty arthritis: A retrospective observational study of Japanese health insurance claims data

Purpose This study assessed factors associated with achieving target serum uric acid (sUA) level and occurrence of gouty arthritis in Japanese clinical practice. Methods Japanese health insurance claims and medical check‐up data from October 2015 to March 2017 were analyzed to assess factors associa...

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Bibliographic Details
Published in:Pharmacoepidemiology and drug safety 2021-02, Vol.30 (2), p.157-168
Main Authors: Koto, Ruriko, Nakajima, Akihiro, Horiuchi, Hideki, Yamanaka, Hisashi
Format: Article
Language:English
Subjects:
Allopurinol
Antidiabetics
Arthritis
Diabetes mellitus
Diuretics
epidemiology
Epidermal growth factor receptors
Gout
Hyperuricemia
Insurance claims
Observational studies
Original Report
Original Reports
Patients
pharmacoepidemiology
Renal function
Rheumatism
Risk factors
Uric acid
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Summary:Purpose This study assessed factors associated with achieving target serum uric acid (sUA) level and occurrence of gouty arthritis in Japanese clinical practice. Methods Japanese health insurance claims and medical check‐up data from October 2015 to March 2017 were analyzed to assess factors associated with target sUA achievement in gout and asymptomatic hyperuricemia and gouty arthritis in gout. Target sUA was further assessed by subgroup analysis of urate‐lowering therapy (ULT) prescriptions and outcomes, stratified by renal function. Results Patients achieving target sUA tended toward older, female, higher ULT dose, higher adherence, more comorbidities, and/or antidiabetic drugs prescribed. Renal dysfunction and/or diuretic prescriptions were associated with reduced achievement of target sUA. Severe renal dysfunction was particularly influential (odds ratio [OR] = 0.22 [95% confidence interval (CI): 0.10‐0.48] for
ISSN:1053-8569
1099-1557
DOI:10.1002/pds.5127