Proteinuria in COVID-19: prevalence, characterization and prognostic role

Background Proteinuria has been commonly reported in patients with COVID-19. However, only dipstick tests have been frequently used thus far. Here, the quantification and characterization of proteinuria were investigated and their association with mortality was assessed. Methods This retrospective,...

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Bibliographic Details
Published in:Journal of nephrology 2021-04, Vol.34 (2), p.355-364
Main Authors: Huart, Justine, Bouquegneau, Antoine, Lutteri, Laurence, Erpicum, Pauline, Grosch, Stéphanie, Résimont, Guillaume, Wiesen, Patricia, Bovy, Christophe, Krzesinski, Jean-Marie, Thys, Marie, Lambermont, Bernard, Misset, Benoît, Pottel, Hans, Mariat, Christophe, Cavalier, Etienne, Burtey, Stéphane, Jouret, François, Delanaye, Pierre
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
alpha1-microglobulin
Anesthesia & intensive care
Anesthésie & soins intensifs
Belgium - epidemiology
Biomarkers - urine
Business & economic sciences
COVID-19
COVID-19 - complications
COVID-19 - epidemiology
COVID-19 - urine
Female
Gestion des systèmes d’information
Human health and pathology
Human health sciences
Humans
Laboratory medicine & medical technology
Life Sciences
Male
Management information systems
Medicine
Medicine & Public Health
Middle Aged
Médecine de laboratoire & technologie médicale
Nephrology
Original
Original Article
Prevalence
Prognosis
Proteinuria
Proteinuria - epidemiology
Proteinuria - etiology
Proteinuria - urine
Public health, health care sciences & services
Retrospective Studies
Santé publique, services médicaux & soins de santé
Sciences de la santé humaine
Sciences économiques & de gestion
Survival Rate - trends
Tutubar protéinuria
Urologie & néphrologie
Urology
Urology & nephrology
Urology and Nephrology
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Description
Summary:Background Proteinuria has been commonly reported in patients with COVID-19. However, only dipstick tests have been frequently used thus far. Here, the quantification and characterization of proteinuria were investigated and their association with mortality was assessed. Methods This retrospective, observational, single center study included 153 patients, hospitalized with COVID-19 between March 28th and April 30th, 2020, in whom total proteinuria and urinary α 1 -microglobulin (a marker of tubular injury) were measured. Association with mortality was evaluated, with a follow-up until May 7th, 2020. Results According to the Kidney Disease Improving Global Outcomes staging, 14% (n = 21) of the patients had category 1 proteinuria (
ISSN:1121-8428
1724-6059
1724-6059
DOI:10.1007/s40620-020-00931-w