Hypertension and Its Associations with Dental Status: Data from the Dental, Oral, Medical Epidemiological (DOME) Nationwide Records-Based Study

• Published in: Journal of clinical medicine 2021-01, Vol.10 (2), p.176
• Main Authors: Almoznino, Galit, Zini, Avraham, Kedem, Ron, Protter, Noam E, Zur, Dorit, Abramovitz, Itzhak
• Format: Article
• Language: English
• Subjects: Cardiovascular disease; Chronic illnesses; Clinical medicine; Codes; Data collection; Dental caries; Diabetes; Hypertension; Hypotheses; Medical records; Metabolic syndrome; Middle age; Military personnel; Sociodemographics; Teeth; Variables
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm10020176

Conflicting results have been published regarding the associations between dental status and hypertension. This study aims to explore whether or not hypertension is associated with dental status among young to middle-aged adults. To that end, data from the Dental, Oral, Medical Epidemiological (DOME) study were analyzed. The DOME is a cross-sectional records-based study that combines comprehensive socio-demographic, medical, and dental databases of a nationally representative sample of military personnel. Included were 132,529 subjects aged 18-50 years who attended the military dental clinics for one year. The prevalence of hypertension in the study population was 2.5% (3363/132,529). Following multivariate analysis, the associations between hypertension and dental parameters were lost and hypertension retained a positive association with obesity (Odds ratio (OR) = 4.2 (3.7-4.9)), diabetes mellitus (OR = 4.0 (2.9-5.7)), birth country of Western Europe vs. Israeli birth country (OR = 1.9 (1.6-2.2)), male sex (OR = 1.9 (1.6-2.2)), cardiovascular disease (OR = 1.9 (1.6-2.3)), presence of fatty liver (OR = 1.8 (1.5-2.3)), the birth country Asia vs. Israeli birth country (OR = 1.6 (1.1-2.3)), smoking (OR = 1.2 (1.05-1.4)), and older age (OR = 1.05 (1.04-1.06)). Further analysis among an age-, smoking- and sex matched sub-population ( = 13,452) also revealed that the dental parameters lost their statistically significant association with hypertension following multivariate analysis, and hypertension retained a positive association with diabetes (OR = 4.08 (2.6-6.1)), obesity (OR = 2.7 (2.4-3.2)), birth country of Western Europe vs. Israel (OR = 1.9 (1.6-2.3)), cardiovascular disease (OR = 1.8 (1.5-2.2)), fatty liver (OR = 1.7 (1.3-2.3)), high school education vs. academic (OR = 1.5 (1.3-1.8)), and low socio-economic status (SES) vs. high (OR = 1.4 (1.03-1.8)). We analyzed the associations between C-reactive protein (CRP) and dental parameters and combined the statistically significant variables to create a dental inflammation score (DIS). This crated a final model with the appropriate weights written as follows: DIS = (periodontal disease × 14) + (the number of teeth that required crowns × 11) + (missing teeth × 75). The mean DIS was 10.106 ± 25.184, and it exhibited a weak positive association with hypertension in the univariate analysis (OR = 1.011 (1.010-1.012)). Receiver operating characteristic (ROC) analysis of the DIS against hypertension produced a faile