Altered Spatial Composition of the Immune Cell Repertoire in Association to CD34 + Blasts in Myelodysplastic Syndromes and Secondary Acute Myeloid Leukemia

: Myelodysplastic syndromes (MDS) are caused by a stem cell failure and often include a dysfunction of the immune system. However, the relationship between spatial immune cell distribution within the bone marrow (BM), in relation to genetic features and the course of disease has not been analyzed in...

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Bibliographic Details
Published in:Cancers 2021-01, Vol.13 (2), p.186
Main Authors: Bauer, Marcus, Vaxevanis, Christoforos, Al-Ali, Haifa Kathrin, Jaekel, Nadja, Naumann, Christin Le Hoa, Schaffrath, Judith, Rau, Achim, Seliger, Barbara, Wickenhauser, Claudia
Format: Article
Language:English
Subjects:
Acute myeloid leukemia
Blood diseases
Bone marrow
CD34 antigen
CD8 antigen
Deregulation
Disease
Epigenetics
Foxp3 protein
Immune system
Leukemia
Lymphocytes
Lymphocytes T
Mutation
Myelodysplastic syndrome
Myeloid leukemia
Pathogenesis
Patients
Plasma
Plasma cells
Signal transduction
Spatial distribution
Stem cells
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Summary:: Myelodysplastic syndromes (MDS) are caused by a stem cell failure and often include a dysfunction of the immune system. However, the relationship between spatial immune cell distribution within the bone marrow (BM), in relation to genetic features and the course of disease has not been analyzed in detail. : Histotopography of immune cell subpopulations and their spatial distribution to CD34 hematopoietic cells was determined by multispectral imaging (MSI) in 147 BM biopsies (BMB) from patients with MDS, secondary acute myeloid leukemia (sAML), and controls. : In MDS and sAML samples, a high inter-tumoral immune cell heterogeneity in spatial proximity to CD34 blasts was found that was independent of genetic alterations, but correlated to blast counts. In controls, no CD8 and FOXP3 T cells and only single MUM1p B/plasma cells were detected in an area of ≤10 μm to CD34 HSPC. : CD8 and FOXP3 T cells are regularly seen in the 10 μm area around CD34 blasts in MDS/sAML regardless of the course of the disease but lack in the surrounding of CD34 HSPC in control samples. In addition, the frequencies of immune cell subsets in MDS and sAML BMB differ when compared to control BMB providing novel insights in immune deregulation.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13020186