Evaluation of repeat cytoreductive surgery and heated intraperitoneal chemotherapy for patients with recurrent peritoneal carcinomatosis from appendiceal and colorectal cancers: a multicentre Canadian study

• Published in: Canadian Journal of Surgery 2020-02, Vol.63 (1), p.E71-E79
• Main Authors: Jost, Evan, Mack, Lloyd A., Sideris, Lucas, Dube, Pierre, Temple, Walley, Bouchard-Fortier, Antoine
• Format: Article
• Language: English
• Subjects: Adult; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Appendiceal Neoplasms - mortality; Appendiceal Neoplasms - pathology; Appendiceal Neoplasms - therapy; Canada - epidemiology; Cancer metastasis; Cancer recurrence; Cancer research; Cancer treatment; Carcinoma; Carcinoma - mortality; Carcinoma - secondary; Carcinoma - therapy; Care and treatment; Chemotherapy; Colorectal cancer; Colorectal Neoplasms - mortality; Colorectal Neoplasms - pathology; Colorectal Neoplasms - therapy; Combined Modality Therapy; Cross-Sectional Studies; Cytoreduction Surgical Procedures - adverse effects; Cytoreduction Surgical Procedures - mortality; Debulking; Digestive system cancer; Diseases; Feasibility Studies; Female; Gastric cancer; Humans; Hyperthermia, Induced - adverse effects; Hyperthermic intraperitoneal chemotherapy; Intervention; Male; Medical prognosis; Medical research; Metastasis; Middle Aged; Morbidity; Mortality; Neoplasm Recurrence, Local - mortality; Neoplasm Recurrence, Local - therapy; Outcome Assessment, Health Care; Patient outcomes; Patients; Peritoneal Neoplasms - mortality; Peritoneal Neoplasms - secondary; Peritoneal Neoplasms - therapy; Recurrence (Disease); Reoperation - adverse effects; Reoperation - mortality; Retrospective Studies; Statistical analysis; Studies; Surgery; Systematic review; Time; Tumors
• ISSN: 0008-428X; 1488-2310
• DOI: 10.1503/cjs.002519

Peritoneal recurrences after cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) for appendiceal and colorectal cancers are frequent. This study aimed to evaluate the safety, technical feasibility and perioperative and long-term outcomes of repeat CRS/HIPEC in patients with recurrent peritoneal carcinomatosis of colorectal and appendiceal origin. Data were collected from patients treated from 2000 to 2016 for recurrent peritoneal carcinomatosis from appendiceal or colorectal cancer with CRS/HIPEC at 2 specialist centres. Data on demographics, procedure details, morbidity and survival were recorded. Analyses compared the iterations of CRS/HIPEC to assess the safety and effectiveness of repeat surgery. Of all patients who underwent CRS/HIPEC in the 2 centres, 37 patients underwent a repeat procedure. Operative time was similar for the first and second surgeries (412.1 v. 412.5 min, p = 0.74) but patients had a significantly lower peritoneal carcinoma index score with the second surgery (21.8 in the first iteration v. 9.53 in the second iteration, p < 0.001) and significantly less blood loss (1762 mL in the first iteration v. 790 mL in the second iteration, p = 0.001). There was a nonsignificant decrease in grade III–IV complications and there was no 30-day mortality associated with repeat procedures. For patients with colorectal cancer, median disease-free survival was 9.6 months and median overall survival was 40 months. For patients with appendiceal cancer, median disease-free survival was 15 months and overall survival was 64.4 months. Repeat CRS/HIPEC procedures for recurrent appendiceal and colorectal peritoneal carcinomatosis are safe in well-selected patients, without increased morbidity or mortality, and they are associated with significant long-term survival, particularly for patients with appendiceal cancers. These results support the use of repeat CRS/HIPEC in these patients.