Amikacin or Vancomycin Exposure Alters the Postnatal Serum Creatinine Dynamics in Extreme Low Birth Weight Neonates

Disentangling renal adverse drug reactions from confounders remains a major challenge to assess causality and severity in neonates, with additional limitations related to the available tools (modified Kidney Disease Improving Global Outcome, or Division of Microbiology and Infectious Diseases pediat...

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Bibliographic Details
Published in:International journal of environmental research and public health 2021-01, Vol.18 (2), p.662
Main Authors: van Donge, Tamara, Smits, Anne, van den Anker, John, Allegaert, Karel
Format: Article
Language:English
Subjects:
Amikacin
Amikacin - toxicity
Anti-Bacterial Agents - toxicity
Antibiotics
Birth weight
Cesarean section
Child
Creatinine
Datasets
Dynamic models
Exposure
Gestational age
Humans
Infant, Low Birth Weight
Infant, Newborn
Infectious diseases
Intensive care
Kidney diseases
Kidneys
Laboratories
Ligands
Low birth weight
Microbiology
Neonates
Nonsteroidal anti-inflammatory drugs
Physiology
Population
Renal function
Side effects
Toxicity
Toxicology
Trends
Values
Vancomycin
Vancomycin - toxicity
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Summary:Disentangling renal adverse drug reactions from confounders remains a major challenge to assess causality and severity in neonates, with additional limitations related to the available tools (modified Kidney Disease Improving Global Outcome, or Division of Microbiology and Infectious Diseases pediatric toxicity table). Vancomycin and amikacin are nephrotoxic while still often prescribed in neonates. We selected these compounds to assess their impact on creatinine dynamics as a sensitive tool to detect a renal impairment signal. A recently developed dynamical model that characterized serum creatinine concentrations of 217 extremely low birth weight (
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph18020662