Inflammatory and hematologic markers as predictors of severe outcomes in COVID-19 infection: A systematic review and meta-analysis

Laboratory testing is commonly performed in patients with COVID-19. Each of the laboratory parameters has potential value for risk stratification and prediction of COVID-19 outcomes. This systematic review and meta-analysis aimed to evaluate the difference between these parameters in severe and nons...

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Bibliographic Details
Published in:The American journal of emergency medicine 2021-03, Vol.41, p.110-119
Main Authors: Hariyanto, Timotius Ivan, Japar, Karunia Valeriani, Kwenandar, Felix, Damay, Vika, Siregar, Jeremia Immanuel, Lugito, Nata Pratama Hardjo, Tjiang, Margaret Merlyn, Kurniawan, Andree
Format: Article
Language:English
Subjects:
Albumin
Biomarker
Biomarkers
Biomarkers - blood
C-reactive protein
C-Reactive Protein - metabolism
Coronavirus
Coronaviruses
COVID-19
COVID-19 - blood
COVID-19 - complications
COVID-19 - diagnosis
COVID-19 Serological Testing
Disease transmission
Emergency medical care
Fibrin Fibrinogen Degradation Products - metabolism
Humans
Infections
Inflammation
L-Lactate dehydrogenase
L-Lactate Dehydrogenase - blood
Laboratories
Laboratory
Laboratory tests
Lactic acid
Meta-analysis
Pneumonia
Procalcitonin
Procalcitonin - blood
Prognosis
Proteins
Risk Assessment
SARS-CoV-2
Serum Albumin - metabolism
Severe acute respiratory syndrome coronavirus 2
Severity of Illness Index
Systematic review
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Description
Summary:Laboratory testing is commonly performed in patients with COVID-19. Each of the laboratory parameters has potential value for risk stratification and prediction of COVID-19 outcomes. This systematic review and meta-analysis aimed to evaluate the difference between these parameters in severe and nonsevere disease and to provide the optimal cutoff value for predicting severe disease. We performed a systematic literature search through electronic databases. The variables of interest were serum procalcitonin, albumin, C-reactive protein (CRP), D-dimer, and lactate dehydrogenase (LDH) levels in each group of severity outcomes from COVID-19. There were a total of 4848 patients from 23 studies. Our meta-analysis suggest that patients with severe COVID-19 infections have higher procalcitonin, (mean difference 0.07; 95% CI 0.05–0.10; p 
ISSN:0735-6757
1532-8171
DOI:10.1016/j.ajem.2020.12.076