Importance of hyperglycemia in COVID-19 intensive-care patients: Mechanism and treatment strategy

•COVID-19 patients develop hyperglycemia and related complication.•COVID-19 is associated with increased risk for development of diabetes in future.•Hyperglycemia is an important factor in all operative periods.•Hyperglycemia strongly elevated risk of organs failure, and death.•Hyperglycemia is stro...

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Bibliographic Details
Published in:Primary care diabetes 2021-06, Vol.15 (3), p.409-416
Main Authors: Mirzaei, Fatemeh, Khodadadi, Iraj, Vafaei, Seyyed Alireza, Abbasi-Oshaghi, Ebrahim, Tayebinia, Heidar, Farahani, Farhad
Format: Article
Language:English
Subjects:
Biomarkers - blood
Blood Glucose - metabolism
Coronavirus
COVID-19
COVID-19 - complications
COVID-19 - epidemiology
Diabetes
Disease Management
Global Health
Hospitalization - trends
Humans
Hyperglycemia
Hyperglycemia - epidemiology
Hyperglycemia - etiology
Hyperglycemia - therapy
Incidence
Intensive Care Units
Oxidative stress
Pandemics
Review
SARS-CoV-2
Survival Rate - trends
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Summary:•COVID-19 patients develop hyperglycemia and related complication.•COVID-19 is associated with increased risk for development of diabetes in future.•Hyperglycemia is an important factor in all operative periods.•Hyperglycemia strongly elevated risk of organs failure, and death.•Hyperglycemia is strong predictors of organ failure and mortality rate. This review reported that coronavirus disease 2019 (COVID-19) infected patients with short time bed rest or quarantine and airway inflammation are at more risk of developing hyperglycemia and insulin resistance. This condition can induce oxidative stress, decrease immune system function, impair endothelial function, induce apoptosis, and reduce antioxidant in the lungs. We provide a possible mechanism in severe COVID-19 patients and recommend treatment strategy to reduce mortality rate and prevent adverse outcomes after intensive care unit (ICU).
ISSN:1751-9918
1878-0210
1878-0210
DOI:10.1016/j.pcd.2021.01.002