Evaluation of hydrogen peroxide-assisted endoscopic ultrasonography-guided necrosectomy in walled-off pancreatic necrosis: A single-center experience

Hydrogen peroxide is a liquid that functions in mechanical removal of the necrotic tissue via the elimination of tissue debris.In this study, we aimed to evaluate the effectiveness of the use of hydrogen peroxide in necrosectomy treatment of walled-off pancreatic necrosis.Records of 24 patients who...

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Bibliographic Details
Published in:Medicine (Baltimore) 2021-01, Vol.100 (3), p.e23175-e23175
Main Authors: Günay, Süleyman, Paköz, Betül, Çekiç, Cem, Çamyar, Hakan, Alper, Emrah, Yüksel, Elif Saritaş, Topal, Firdevs, Binicier, Ömer Burcak
Format: Article
Language:English
Subjects:
Endosonography
Female
Humans
Hydrogen Peroxide - administration & dosage
Male
Middle Aged
Observational Study
Oxidants - administration & dosage
Pancreatitis, Acute Necrotizing - diagnostic imaging
Pancreatitis, Acute Necrotizing - surgery
Retrospective Studies
Treatment Outcome
Ultrasonography, Interventional
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Summary:Hydrogen peroxide is a liquid that functions in mechanical removal of the necrotic tissue via the elimination of tissue debris.In this study, we aimed to evaluate the effectiveness of the use of hydrogen peroxide in necrosectomy treatment of walled-off pancreatic necrosis.Records of 24 patients who were diagnosed with pancreatic necrosis or walled-off pancreatic necrosis and underwent endoscopic necrosectomy (EN) were retrospectively assessed. Patients were divided into 2 groups; hydrogen peroxide used for treatment or not used, and these 2 groups were compared.A total of 24 patients underwent endoscopic intervention for walled-off pancreatic necrosis. Procedural success was comparable between the 2 groups. During the post-procedural follow-up, the duration of the hospital stay, recurrence, and complication rates were found to be similar in both groups. The mean number of the endoscopic interventions was significantly lower in the hydrogen peroxide group (4.2 ± 1.4 vs 6.1 ± 4.2; P = .01).The use of hydrogen peroxide for EN in walled-off pancreatic necrosis patients seems to have similar efficiency and safety. However, it can be said that the use of hydrogen peroxide could reduce the number of endoscopic procedures.
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000023175