Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions

Abstract We documented dramatic responses to infliximab in 4 tuberculous meningitis cases with severe paradoxical reactions after effective antibacterial treatment, despite high-dose steroids. In every instance, infliximab was used as a last resort after all other options were exhausted, resulting i...

Full description

Saved in:
Bibliographic Details
Published in:Open forum infectious diseases 2021-01, Vol.8 (1), p.ofaa604-ofaa604
Main Authors: Marais, Ben J, Cheong, Elaine, Fernando, Shelanah, Daniel, Santhosh, Watts, Matthew R, Berglund, Lucinda J, Barry, Simone E, Kotsiou, George, Headley, Alex P, Stapledon, Richard A
Format: Article
Language:English
Subjects:
Brief Report
Editor's Choice
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract We documented dramatic responses to infliximab in 4 tuberculous meningitis cases with severe paradoxical reactions after effective antibacterial treatment, despite high-dose steroids. In every instance, infliximab was used as a last resort after all other options were exhausted, resulting in delayed initiation that may have adversely affected patient outcomes. We documented dramatic responses to infliximab in four tuberculous meningitis cases with paradoxical reactions unresponsive to high dose steroids. Infliximab was only used as a last resort after all other options were exhausted, but there is scope for earlier consideration.
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofaa604