Clinical features of asthma with comorbid bronchiectasis: A systematic review and meta-analysis

This meta-analysis aimed to systematically estimate the prevalence of comorbid bronchiectasis in patients with asthma and to summarize its clinical impact. Embase, PubMed, and Cochrane Library electronic databases were searched to identify relevant studies published from inception until March 2020....

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Bibliographic Details
Published in:Medicine (Baltimore) 2021-01, Vol.100 (4), p.e23858-e23858
Main Authors: Zhang, Shi-Qi, Xiong, Xiao-Feng, Wu, Zuo-Hong, Huang, Ting-Ting, Cheng, De-Yun
Format: Article
Language:English
Subjects:
Asthma - complications
Asthma - epidemiology
Asthma - physiopathology
Biomarkers - blood
Bronchiectasis - complications
Bronchiectasis - epidemiology
Bronchiectasis - physiopathology
Comorbidity
Eosinophils - metabolism
Forced Expiratory Volume
Humans
Prevalence
Risk Factors
Severity of Illness Index
Systematic Review and Meta-Analysis
Vital Capacity
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Summary:This meta-analysis aimed to systematically estimate the prevalence of comorbid bronchiectasis in patients with asthma and to summarize its clinical impact. Embase, PubMed, and Cochrane Library electronic databases were searched to identify relevant studies published from inception until March 2020. Studies were included if bronchiectasis was identified by high-resolution computed tomography. Outcomes included the prevalence of bronchiectasis and its association with demographic characteristics and indicators of asthma severity, including results of lung function tests and the number of exacerbations. Five observational studies with 839 patients were included. Overall, the mean prevalence of bronchiectasis in patients with asthma was 36.6% (307/839). Patients with comorbid bronchiectasis had lower forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) (MD: -2.71; 95% CI: -3.72 to -1.69) and more frequent exacerbations (MD: 0.68; 95% CI: 0.03 to 1.33) than those with asthma alone, and there was no significant difference of sex, duration of asthma and serum levels of immunoglobulin(Ig)Es between asthmatic patients with or without bronchiectasis. The presence of bronchiectasis in patients with asthma was associated with greater asthma severity. There are important therapeutic implications of identifying bronchiectasis in asthmatic patients.
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000023858