A case-control study exploring the role of serum manganese superoxide dismutase (MnSOD) levels in gastric cancer

The role of serum manganese superoxide dismutase (MnSOD) in the development of gastric cancer has not been clearly defined. We conducted a case-control study to address the potential relationship between serum MnSOD levels and gastric cancer. Cases were 275 gastric cancer patients and controls were...

Full description

Saved in:
Bibliographic Details
Published in:Journal of epidemiology 2005, Vol.15 (3), p.90-95
Main Authors: Lin, Yingsong, Kikuchi, Shogo, Obata, Yuki, Yagyu, Kiyoko
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Female
Humans
Japan - epidemiology
Male
Middle Aged
Original
Risk Factors
Stomach Neoplasms - enzymology
Stomach Neoplasms - epidemiology
Superoxide Dismutase - blood
Superoxide Dismutase - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The role of serum manganese superoxide dismutase (MnSOD) in the development of gastric cancer has not been clearly defined. We conducted a case-control study to address the potential relationship between serum MnSOD levels and gastric cancer. Cases were 275 gastric cancer patients and controls were 275 sex and age-matched healthy persons. Serum MnSOD levels were determined by a commercially available enzyme-linked immunosorbent assay (ELISA). The mean(+/-standard deviation) of serum MnSOD levels was 177.4 +/- 87.3 ng/mL among cases and 169.4 +/- 56.7 ng/mL among controls. Gastric cancer patients had slightly higher serum MnSOD levels than the controls. After adjustment for pack-years of cigarette smoking and Helicobacter pylori infection, the odds ratio was 1.54(95% confidence interval; 0.79-3.01) for subjects in the highest quartile versus the lowest quartile. No significant differences were observed for serum MnSOD levels in gastric cancer patients according to clinicopathological factors such as disease stage, histological type, venous invasion, and lymph node metastasis. Our study suggested that serum MnSOD levels are not significantly associated with the increased risk of gastric cancer, although a weak association may exist.
ISSN:0917-5040
1349-9092
DOI:10.2188/jea.15.90