The impact of endometrioma on in vitro fertilisation/intra-cytoplasmic injection IVF/ICSI reproductive outcomes: a systematic review and meta-analysis

Background Assisted reproductive technologies (ART) such as in vitro fertilisation (IVF) and intra-cytoplasmic sperm injection (ICSI) are often used to aid fertility in women with endometrioma; however, the implications of endometrioma on ART are unresolved. Objective To determine the effect of endo...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2021-01, Vol.303 (1), p.3-16
Main Authors: Alshehre, Sallwa M., Narice, Brenda F., Fenwick, Mark A., Metwally, Mostafa
Format: Article
Language:English
Subjects:
Birth Rate
Confidence intervals
Cysts
Drug dosages
Embryo Implantation
Endocrinology
Endometriosis
Endometriosis - complications
Endometriosis - pathology
Female
Fertilization in Vitro - methods
Gonadotropins - administration & dosage
Gynecology
Human Genetics
Humans
In vitro fertilization
Infertility
Medicine
Medicine & Public Health
Meta-analysis
Metabolism
Obstetrics
Obstetrics/Perinatology/Midwifery
Oocytes
Ovaries
Pregnancy
Pregnancy Rate
Reproductive technologies
Review
Sperm
Sperm Injections, Intracytoplasmic - methods
Systematic review
Treatment Outcome
Womens health
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Summary:Background Assisted reproductive technologies (ART) such as in vitro fertilisation (IVF) and intra-cytoplasmic sperm injection (ICSI) are often used to aid fertility in women with endometrioma; however, the implications of endometrioma on ART are unresolved. Objective To determine the effect of endometrioma on reproductive outcomes in women undergoing IVF or ICSI. Methods A systematic review and meta-analysis was conducted to identify articles examining women who had endometrioma and had undergone IVF or ICSI. Electronic searches were performed in PubMed, BIOSIS and MEDLINE up to September 2019. The primary outcome was live birth rate (LBR). Secondary outcomes included clinical pregnancy rate (CPR), implantation rate (IR), number of oocytes retrieved, number of metaphase II (MII) oocytes retrieved, number of embryos and top-quality embryos and the duration of gonadotrophin stimulation and dose. Results Eight studies were included. Where significant heterogeneity between studies was identified, a random-effects model was used. The number of oocytes (weighted means difference; WMD-2.25; 95% CI 3.43 to − 1.06, p  = 0.0002) and the number of MII oocytes retrieved (WMD-4.64; 95% CI 5.65 to − 3.63, p  
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-020-05796-9