It Is Time to Rethink Biomarkers for Surveillance of Small Bowel Neuroendocrine Tumors

Background Tumor biomarkers (TBMs) reflect disease burden and correlate with survival for small bowel neuroendocrine tumors (SBNETs). This study sought to determine the performance of chromogranin A (CgA), pancreastatin (PST), neurokinin A (NKA), and serotonin (5HT) during follow-up assessment of re...

Full description

Saved in:
Bibliographic Details
Published in:Annals of surgical oncology 2021-02, Vol.28 (2), p.732-741
Main Authors: Tran, Catherine G., Sherman, Scott K., Scott, Aaron T., Ear, Po Hien, Chandrasekharan, Chandrikha, Bellizzi, Andrew M., Dillon, Joseph S., O’Dorisio, Thomas M., Howe, James R.
Format: Article
Language:English
Subjects:
Accuracy
Biomarkers
Biomarkers, Tumor
Chromogranin A
Female
Gastrointestinal Oncology
Humans
Intestinal Neoplasms - surgery
Intestine, Small - surgery
Male
Medicine
Medicine & Public Health
Metastases
Metastasis
Neuroendocrine tumors
Neuroendocrine Tumors - surgery
Neurokinin
Neurokinin A
Oncology
Pancreatic Neoplasms
Serotonin
Small intestine
Stomach Neoplasms
Surgery
Surgical Oncology
Surveillance
Survival
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Tumor biomarkers (TBMs) reflect disease burden and correlate with survival for small bowel neuroendocrine tumors (SBNETs). This study sought to determine the performance of chromogranin A (CgA), pancreastatin (PST), neurokinin A (NKA), and serotonin (5HT) during follow-up assessment of resected SBNETs. Methods An institutional database identified patients undergoing surgery for SBNETs. Tumor biomarker levels were assessed as categorical (normal vs elevated) and continuous variables for association with progression-free survival (PFS) and overall survival (OS) via the Kaplan–Meier method with Cox multivariable models adjusted for confounders. Sensitivity, specificity, and predictive values of TBM levels in identifying imaging-confirmed progression were calculated. Results In 218 patients (44% female, 92% node + , 73% metastatic, 97% G1 or G2), higher levels of CgA, PST, NKA, and 5HT correlated with higher-grade and metastatic disease at presentation ( p  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-020-08784-0