The Role of Actin in Muscle Spasms in a Case Series of Patients with Advanced Basal Cell Carcinoma Treated with a Hedgehog Pathway Inhibitor

Basal cell carcinoma (BCC) is the most common cancer globally, with the incidence increasing worldwide by approximately 1% annually. While most cases of BCC can be treated surgically, advanced BCC often poses treatment challenges for patients unsuitable for, or refractory to, radiotherapy and surger...

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Bibliographic Details
Published in:Dermatology and therapy 2021-02, Vol.11 (1), p.293-299
Main Authors: Teh, Natalie, Leow, Liang Joo
Format: Article
Language:English
Subjects:
Actin
Basal cell carcinoma
Case Series
Causes of
Dermatology
Drug therapy
Health aspects
Hedgehog proteins
Internal Medicine
Medicine
Medicine & Public Health
Oral and Maxillofacial Surgery
Physiological aspects
Plastic Surgery
Quality of Life Research
Spasms
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Summary:Basal cell carcinoma (BCC) is the most common cancer globally, with the incidence increasing worldwide by approximately 1% annually. While most cases of BCC can be treated surgically, advanced BCC often poses treatment challenges for patients unsuitable for, or refractory to, radiotherapy and surgery. Since the majority of cases of BCC demonstrate Hedgehog signaling hyperactivation, Hedgehog pathway inhibitors provide durable treatment options and improved clinical outcomes for patients with advanced BCC. One of the most common adverse events seen in patients taking Hedgehog inhibitors includes muscle spasms, which are hypothesized to occur because of calcium influx into the muscle cells. Here we present a case series of patients with muscle spasms during treatment with sonidegib and propose an alternate etiology related to increased actin expression.
ISSN:2193-8210
2190-9172
DOI:10.1007/s13555-020-00464-x