sym-2 loss-of-function causes glutamatergic neurodegeneration after oxidative stress

Although some RNA-binding proteins are known to contribute to neurodegeneration, the genetic interaction between the genes encoding these proteins is unclear. Here, we examine the interaction between , the gene encoding an ortholog of hnRNPF and hnRNPH, and , the ortholog of of the gene encoding hnR...

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Bibliographic Details
Published in:microPublication biology 2021-02, Vol.2021
Main Authors: Ryan, Veronica H, Hart, Anne C
Format: Article
Language:English
Subjects:
New Finding
Phenotype Data
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Summary:Although some RNA-binding proteins are known to contribute to neurodegeneration, the genetic interaction between the genes encoding these proteins is unclear. Here, we examine the interaction between , the gene encoding an ortholog of hnRNPF and hnRNPH, and , the ortholog of of the gene encoding hnRNPA2, which when mutated causes multisystem proteinopathy. We find that after 22 hours, but not 4 hours, of paraquat-induced oxidative stress, has a mild glutamatergic neurodegeneration phenotype. Interestingly, this defect is rescued by expression of chimeric WT , but not mutant. Thus, we identify a curious genetic interaction between and .
ISSN:2578-9430
DOI:10.17912/micropub.biology.000363