Randomized controlled trial comparing embryonic quality in rFSH versus hMG in the IVF protocol with GnRH Antagonist

The aim of the present study is to investigate embryo quality (score) after controlled ovarian stimulation for IVF using rFSH or hMG with the GnRH antagonist protocol. Open, randomized, single center study. The patients were randomized to receive rFSH or hMG according to randomized cards inside a bl...

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Bibliographic Details
Published in:JBRA assisted reproduction 2021-01, Vol.25 (1), p.131-135
Main Authors: Chapon, Rita de Cassia Borges, Genro, Vanessa Krebs, Souza, Carlos Augusto Bastos de, Cunha-Filho, João Sabino
Format: Article
Language:English
Subjects:
Body mass index
Cell division
Cysts
Embryos
Female
Fertilization in Vitro
Follicle Stimulating Hormone
Gonadotropin-Releasing Hormone
Humans
Infertility
Original
Ovaries
Ovulation Induction
Pharmaceutical industry
Pregnancy
Pregnancy Rate
Recombinant Proteins
Standard deviation
Statistical analysis
Ultrasonic imaging
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Summary:The aim of the present study is to investigate embryo quality (score) after controlled ovarian stimulation for IVF using rFSH or hMG with the GnRH antagonist protocol. Open, randomized, single center study. The patients were randomized to receive rFSH or hMG according to randomized cards inside a black envelope with the name of the respective treatment following a computer generated list (85 patients were allocated to rFSH group and 83 patients to hMG group). Inclusion criteria were patients with IVF indication and normal ovarian reserve. Embryo evaluation was performed on day three, after fertilization based on the Graduated Embryo Score (GES). There were no relevant differences in demographic characteristics. There was no difference in pregnancy rates with 27 (31%) and 25 (30.1%) pregnancies for rFSH and hMG, respectively (p=0.87). The total embryo score was the same for both groups, but the best embryo score was significant higher for the rFSH group (77.33±34.0 x 65.07±33.2 p=0.03). The total number of embryos was statistical different, also in favor of the rFSH group (4.17±3.1 x 3.26±2.4 p=0.04). The total embryo score was the same for both groups, but the best embryo score was significantly higher for the rFSH group. Moreover, rFSH was associated with an increased number of embryos.
ISSN:1518-0557
1517-5693
1518-0557
DOI:10.5935/1518-0557.20200064