Heat-shrinking DNA nanoparticles for in vivo gene delivery

The particle size of a PEG-peptide DNA nanoparticle is a key determinant of biodistribution following i.v. dosing. DNA nanoparticles of

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Bibliographic Details
Published in:Gene therapy 2020-05, Vol.27 (5), p.196-208
Main Authors: Mathew, Basil, Ramanathan, Raghu, Delvaux, Nathan A., Poliskey, Jacob, Rice, Kevin G.
Format: Article
Language:English
Subjects:
42/44
45/29
59/5
631/61/2300/1514
631/61/350/354
Biomedical and Life Sciences
Biomedicine
Cell Biology
Denaturation
Deoxyribonucleic acid
DNA
Endothelial cells
Endothelium
Freeze drying
Gene Expression
Gene Therapy
Gene transfer
Hepatocytes
Human Genetics
Kupffer cells
Liver
Nanoparticles
Nanotechnology
Peptides
Proteins
Scavenger receptors
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Description
Summary:The particle size of a PEG-peptide DNA nanoparticle is a key determinant of biodistribution following i.v. dosing. DNA nanoparticles of
ISSN:0969-7128
1476-5462
DOI:10.1038/s41434-019-0117-0