Anti-Rheumatic Effect of Antisense Oligonucleotide Cytos-11 Targeting TNF-α Expression

The urgency of the search for inexpensive and effective drugs with localized action for the treatment of rheumatoid arthritis continues unabated. In this study, for the first time we investigated the Cytos-11 antisense oligonucleotide suppression of TNF-α gene expression in a rat model of rheumatoid...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-01, Vol.22 (3), p.1022
Main Authors: Makalish, Tatyana P, Golovkin, Ilya O, Oberemok, Volodymyr V, Laikova, Kateryna V, Temirova, Zenure Z, Serdyukova, Olesya A, Novikov, Ilya A, Rosovskyi, Roman A, Gordienko, Andrey I, Zyablitskaya, Evgeniya Yu, Gafarova, Elvina A, Yurchenko, Kseniya A, Fomochkina, Iryna I, Kubyshkin, Anatoly V
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antirheumatic Agents - therapeutic use
Antisense oligonucleotides
Antisense therapy
Arthritis
Arthritis, Rheumatoid - drug therapy
Cartilage
Clinical trials
Disease
Drugs
Experiments
Gene expression
Gene Silencing
Infections
Inflammation
Monoclonal antibodies
Morphology
Oligonucleotides, Antisense - therapeutic use
Peripheral blood
Quality of life
Rats
Rats, Wistar
Rheumatoid arthritis
RNA, Messenger - genetics
RNA, Messenger - metabolism
Tumor Necrosis Factor-alpha - blood
Tumor Necrosis Factor-alpha - genetics
Tumor Necrosis Factor-alpha - metabolism
Tumor necrosis factor-TNF
Tumor necrosis factor-α
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Summary:The urgency of the search for inexpensive and effective drugs with localized action for the treatment of rheumatoid arthritis continues unabated. In this study, for the first time we investigated the Cytos-11 antisense oligonucleotide suppression of TNF-α gene expression in a rat model of rheumatoid arthritis induced by complete Freund's adjuvant. Cytos-11 has been shown to effectively reduce peripheral blood concentrations of TNF-α, reduce joint inflammation, and reduce pannus development. The results achieved following treatment with the antisense oligonucleotide Cytos-11 were similar to those of adalimumab (Humira ); they also compared favorably with those results, which provides evidence of the promise of drugs based on antisense technologies in the treatment of this disease.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22031022