Different β‐cell secretory phenotype in non‐obese compared to obese early type 2 diabetes

Background Type 2 diabetes (T2D) is characterized by impaired tissue sensitivity to insulin action (ie, insulin resistance) and impaired β‐cell insulin secretion. Because obesity contributes importantly to the development of insulin resistance, we sought to determine whether insulin secretory defect...

Full description

Saved in:
Bibliographic Details
Published in:Diabetes/metabolism research and reviews 2020-07, Vol.36 (5), p.e3295-n/a
Main Authors: Gudipaty, Lalitha, Rosenfeld, Nora K., Fuller, Carissa S., Cuchel, Marina, Rickels, Michael R.
Format: Article
Language:English
Subjects:
Arginine
Beta cells
Diabetes
Diabetes mellitus (non-insulin dependent)
Glucose
Insulin
Insulin resistance
Insulin secretion
insulin sensitivity
Obesity
Phenotypes
type 2 diabetes
β‐cell function
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Type 2 diabetes (T2D) is characterized by impaired tissue sensitivity to insulin action (ie, insulin resistance) and impaired β‐cell insulin secretion. Because obesity contributes importantly to the development of insulin resistance, we sought to determine whether insulin secretory defects would predominate in non‐obese compared to obese T2D. Methods We measured β‐cell function and secretory capacity using the glucose‐potentiated arginine test in T2D subjects early in the disease course classified as non‐obese (BMI
ISSN:1520-7552
1520-7560
DOI:10.1002/dmrr.3295