Assessing Kidney Graft Viability and Its Cells Metabolism during Machine Perfusion

Kidney transplantation is the golden treatment for end-stage renal disease. Static cold storage is currently considered the standard method of preservation, but dynamic techniques, such as machine perfusion (MP), have been shown to improve graft function, especially in kidneys donated by extended cr...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-01, Vol.22 (3), p.1121
Main Authors: Bellini, Maria Irene, Tortorici, Francesco, Amabile, Maria Ida, D'Andrea, Vito
Format: Article
Language:English
Subjects:
Blood & organ donations
Body temperature
Cold storage
Creatinine
Cryopreservation
Dehydrogenases
End-stage renal disease
Enzymes
Grafting
Ischemia
Kidney diseases
Kidney transplants
Kidneys
Metabolism
Mortality
New technology
Perfusion
Production increases
Quality assessment
Quality control
Review
Transplants & implants
Viability
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Summary:Kidney transplantation is the golden treatment for end-stage renal disease. Static cold storage is currently considered the standard method of preservation, but dynamic techniques, such as machine perfusion (MP), have been shown to improve graft function, especially in kidneys donated by extended criteria donors and donation after circulatory death. With poor organ quality being a major reason for kidneys not being transplanted, an accurate, objective and reliable quality assessment during preservation could add value and support to clinicians' decisions. MPs are emerging technologies with the potential to assess kidney graft viability and quality, both in the hypothermic and normothermic scenarios. The aim of this review is to summarize current tools for graft viability assessment using MP prior to implantation in relation to the ischemic damage.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22031121