MicroRNA function in craniofacial bone formation, regeneration and repair

Bone formation in the craniofacial complex is regulated by cranial neural crest (CNC) and mesoderm-derived cells. Different elements of the developing skull, face, mandible, maxilla (jaws) and nasal bones are regulated by an array of transcription factors, signaling molecules and microRNAs (miRs). m...

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Bibliographic Details
Published in:Bone (New York, N.Y.) N.Y.), 2021-03, Vol.144, p.115789-115789, Article 115789
Main Authors: Hong, Liu, Sun, Hongli, Amendt, Brad A.
Format: Article
Language:English
Subjects:
Animals
Bone development
Bone regeneration
Bone Regeneration - genetics
Bone repair
Humans
Maxilla
microRNA inhibitor system (PMIS)
microRNA mouse models
microRNA therapeutic
MicroRNAs - genetics
Neural Crest
Osteogenesis - genetics
Skull
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Summary:Bone formation in the craniofacial complex is regulated by cranial neural crest (CNC) and mesoderm-derived cells. Different elements of the developing skull, face, mandible, maxilla (jaws) and nasal bones are regulated by an array of transcription factors, signaling molecules and microRNAs (miRs). miRs are molecular modulators of these factors and act to restrict their expression in a temporal-spatial mechanism. miRs control the different genetic pathways that form the craniofacial complex. By understanding how miRs function in vivo during development they can be adapted to regenerate and repair craniofacial genetic anomalies as well as bone diseases and defects due to traumatic injuries. This review will highlight some of the new miR technologies and functions that form new bone or inhibit bone regeneration. [Display omitted] •MicroRNAs regulate genetic pathways that form bone and inhibit bone regeneration.•New microRNA inhibition technology (PMIS) proven in transgenic mice models•MicroRNAs regulate bone formation, inflammation, osteoporosis and periodontitis.•New microRNA inhibition technology (PMIS) more efficacious than oligonucleotides•MicroRNA gene therapy approaches are compared to stem cell-based scaffolds.
ISSN:8756-3282
1873-2763
DOI:10.1016/j.bone.2020.115789