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Acute effects of vagus nerve stimulation parameters on gastric motility assessed with magnetic resonance imaging
Background Vagus nerve stimulation (VNS) is an emerging bioelectronic therapy for regulating food intake and controlling gastric motility. However, the effects of different VNS parameters and polarity on postprandial gastric motility remain incompletely characterized. Methods In anesthetized rats (N...
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| Published in: | Neurogastroenterology and motility 2020-07, Vol.32 (7), p.e13853-n/a |
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| container_title | Neurogastroenterology and motility |
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| creator | Lu, Kun‐Han Cao, Jiayue Phillips, Robert Powley, Terry L. Liu, Zhongming |
| description | Background
Vagus nerve stimulation (VNS) is an emerging bioelectronic therapy for regulating food intake and controlling gastric motility. However, the effects of different VNS parameters and polarity on postprandial gastric motility remain incompletely characterized.
Methods
In anesthetized rats (N = 3), we applied monophasic electrical stimuli to the left cervical vagus and recorded compound nerve action potential (CNAP) as a measure of nerve response. We evaluated to what extent afferent or efferent pathway could be selectively activated by monophasic VNS. In a different group of rats (N = 13), we fed each rat a gadolinium‐labeled meal and scanned the rat stomach with oral contrast‐enhanced magnetic resonance imaging (MRI) while the rat was anesthetized. We evaluated the antral and pyloric motility as a function of pulse amplitude (0.13, 0.25, 0.5, 1 mA), width (0.13, 0.25, 0.5 ms), frequency (5, 10 Hz), and polarity of VNS.
Key Results
Monophasic VNS activated efferent and afferent pathways with about 67% and 82% selectivity, respectively. Primarily afferent VNS increased antral motility across a wide range of parameters. Primarily efferent VNS induced a significant decrease in antral motility as the stimulus intensity increased (R = −.93, P |
| doi_str_mv | 10.1111/nmo.13853 |
| format | article |
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Vagus nerve stimulation (VNS) is an emerging bioelectronic therapy for regulating food intake and controlling gastric motility. However, the effects of different VNS parameters and polarity on postprandial gastric motility remain incompletely characterized.
Methods
In anesthetized rats (N = 3), we applied monophasic electrical stimuli to the left cervical vagus and recorded compound nerve action potential (CNAP) as a measure of nerve response. We evaluated to what extent afferent or efferent pathway could be selectively activated by monophasic VNS. In a different group of rats (N = 13), we fed each rat a gadolinium‐labeled meal and scanned the rat stomach with oral contrast‐enhanced magnetic resonance imaging (MRI) while the rat was anesthetized. We evaluated the antral and pyloric motility as a function of pulse amplitude (0.13, 0.25, 0.5, 1 mA), width (0.13, 0.25, 0.5 ms), frequency (5, 10 Hz), and polarity of VNS.
Key Results
Monophasic VNS activated efferent and afferent pathways with about 67% and 82% selectivity, respectively. Primarily afferent VNS increased antral motility across a wide range of parameters. Primarily efferent VNS induced a significant decrease in antral motility as the stimulus intensity increased (R = −.93, P < .05 for 5 Hz, R = −.85, P < .05 for 10 Hz). The VNS with either polarity tended to promote pyloric motility to a greater extent given increasing stimulus intensity.
Conclusions and Inferences
Monophasic VNS biased toward the afferent pathway is potentially more effective for facilitating occlusive contractions than that biased toward the efferent pathway.
We investigated a possible differential effect of primarily afferent versus efferent cervical VNS on gastric motility under a range of VNS parameters. Gastric MRI data revealed that primarily afferent VNS induced stronger antral contractions relative to primarily efferent VNS. These results could serve as an index for optimizing VNS parameters for promoting gastric motility. </description><identifier>ISSN: 1350-1925</identifier><identifier>EISSN: 1365-2982</identifier><identifier>DOI: 10.1111/nmo.13853</identifier><identifier>PMID: 32297404</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Action potential ; Acute effects ; Electrical stimuli ; Food intake ; Gadolinium ; Gastric motility ; Magnetic resonance imaging ; Motility ; Polarity ; rat ; Rodents ; Sensory neurons ; Vagus nerve ; vagus nerve stimulation</subject><ispartof>Neurogastroenterology and motility, 2020-07, Vol.32 (7), p.e13853-n/a</ispartof><rights>2020 John Wiley & Sons Ltd</rights><rights>2020 John Wiley & Sons Ltd.</rights><rights>Copyright © 2020 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4433-5cff71aa05a3d7d1ea9d2a280f7000c6ab9178da4415af3326e6c18def7b7293</citedby><cites>FETCH-LOGICAL-c4433-5cff71aa05a3d7d1ea9d2a280f7000c6ab9178da4415af3326e6c18def7b7293</cites><orcidid>0000-0001-6689-7058 ; 0000-0002-8773-4204 ; 0000-0002-0355-8515</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27906,27907</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32297404$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, Kun‐Han</creatorcontrib><creatorcontrib>Cao, Jiayue</creatorcontrib><creatorcontrib>Phillips, Robert</creatorcontrib><creatorcontrib>Powley, Terry L.</creatorcontrib><creatorcontrib>Liu, Zhongming</creatorcontrib><title>Acute effects of vagus nerve stimulation parameters on gastric motility assessed with magnetic resonance imaging</title><title>Neurogastroenterology and motility</title><addtitle>Neurogastroenterol Motil</addtitle><description>Background
Vagus nerve stimulation (VNS) is an emerging bioelectronic therapy for regulating food intake and controlling gastric motility. However, the effects of different VNS parameters and polarity on postprandial gastric motility remain incompletely characterized.
Methods
In anesthetized rats (N = 3), we applied monophasic electrical stimuli to the left cervical vagus and recorded compound nerve action potential (CNAP) as a measure of nerve response. We evaluated to what extent afferent or efferent pathway could be selectively activated by monophasic VNS. In a different group of rats (N = 13), we fed each rat a gadolinium‐labeled meal and scanned the rat stomach with oral contrast‐enhanced magnetic resonance imaging (MRI) while the rat was anesthetized. We evaluated the antral and pyloric motility as a function of pulse amplitude (0.13, 0.25, 0.5, 1 mA), width (0.13, 0.25, 0.5 ms), frequency (5, 10 Hz), and polarity of VNS.
Key Results
Monophasic VNS activated efferent and afferent pathways with about 67% and 82% selectivity, respectively. Primarily afferent VNS increased antral motility across a wide range of parameters. Primarily efferent VNS induced a significant decrease in antral motility as the stimulus intensity increased (R = −.93, P < .05 for 5 Hz, R = −.85, P < .05 for 10 Hz). The VNS with either polarity tended to promote pyloric motility to a greater extent given increasing stimulus intensity.
Conclusions and Inferences
Monophasic VNS biased toward the afferent pathway is potentially more effective for facilitating occlusive contractions than that biased toward the efferent pathway.
We investigated a possible differential effect of primarily afferent versus efferent cervical VNS on gastric motility under a range of VNS parameters. Gastric MRI data revealed that primarily afferent VNS induced stronger antral contractions relative to primarily efferent VNS. These results could serve as an index for optimizing VNS parameters for promoting gastric motility. </description><subject>Action potential</subject><subject>Acute effects</subject><subject>Electrical stimuli</subject><subject>Food intake</subject><subject>Gadolinium</subject><subject>Gastric motility</subject><subject>Magnetic resonance imaging</subject><subject>Motility</subject><subject>Polarity</subject><subject>rat</subject><subject>Rodents</subject><subject>Sensory neurons</subject><subject>Vagus nerve</subject><subject>vagus nerve stimulation</subject><issn>1350-1925</issn><issn>1365-2982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kV1rFTEQhoMotlYv_AMS8EYvts3XbnZvhFL8gmpveh_mZCfblN3kmGRPOf_e1FOLCg6BGTIPL-_wEvKas1Ne6yws8ZTLvpVPyDGXXduIoRdP7-eWNXwQ7RF5kfMtY6wTqntOjqQQg1ZMHZPtuV0LUnQObck0OrqDac00YNohzcUv6wzFx0C3kGDBgqlSgU6QS_KWLrH42Zc9hZyxvpHe-XJDF5gClrpPmGOAYJH6-ufD9JI8czBnfPXQT8j1p4_XF1-ay6vPXy_OLxurlJRNa53THIC1IEc9coRhFCB65nQ9w3awGbjuR1CKt-CkFB12lvcjOr3RYpAn5MNBdrtuFhwthpJgNttUbaS9ieDN35vgb8wUd0b3WgjWVYF3DwIp_lgxF7P4bHGeIWBcsxFyYJ2SuuUVffsPehvXFOp1Rije9bxXuq3U-wNlU8w5oXs0w5m5j9HUGM2vGCv75k_3j-Tv3CpwdgDu_Iz7_yuZ79-uDpI_AY0lqiI</recordid><startdate>202007</startdate><enddate>202007</enddate><creator>Lu, Kun‐Han</creator><creator>Cao, Jiayue</creator><creator>Phillips, Robert</creator><creator>Powley, Terry L.</creator><creator>Liu, Zhongming</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6689-7058</orcidid><orcidid>https://orcid.org/0000-0002-8773-4204</orcidid><orcidid>https://orcid.org/0000-0002-0355-8515</orcidid></search><sort><creationdate>202007</creationdate><title>Acute effects of vagus nerve stimulation parameters on gastric motility assessed with magnetic resonance imaging</title><author>Lu, Kun‐Han ; Cao, Jiayue ; Phillips, Robert ; Powley, Terry L. ; Liu, Zhongming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4433-5cff71aa05a3d7d1ea9d2a280f7000c6ab9178da4415af3326e6c18def7b7293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Action potential</topic><topic>Acute effects</topic><topic>Electrical stimuli</topic><topic>Food intake</topic><topic>Gadolinium</topic><topic>Gastric motility</topic><topic>Magnetic resonance imaging</topic><topic>Motility</topic><topic>Polarity</topic><topic>rat</topic><topic>Rodents</topic><topic>Sensory neurons</topic><topic>Vagus nerve</topic><topic>vagus nerve stimulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, Kun‐Han</creatorcontrib><creatorcontrib>Cao, Jiayue</creatorcontrib><creatorcontrib>Phillips, Robert</creatorcontrib><creatorcontrib>Powley, Terry L.</creatorcontrib><creatorcontrib>Liu, Zhongming</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurogastroenterology and motility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Kun‐Han</au><au>Cao, Jiayue</au><au>Phillips, Robert</au><au>Powley, Terry L.</au><au>Liu, Zhongming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute effects of vagus nerve stimulation parameters on gastric motility assessed with magnetic resonance imaging</atitle><jtitle>Neurogastroenterology and motility</jtitle><addtitle>Neurogastroenterol Motil</addtitle><date>2020-07</date><risdate>2020</risdate><volume>32</volume><issue>7</issue><spage>e13853</spage><epage>n/a</epage><pages>e13853-n/a</pages><issn>1350-1925</issn><eissn>1365-2982</eissn><abstract>Background
Vagus nerve stimulation (VNS) is an emerging bioelectronic therapy for regulating food intake and controlling gastric motility. However, the effects of different VNS parameters and polarity on postprandial gastric motility remain incompletely characterized.
Methods
In anesthetized rats (N = 3), we applied monophasic electrical stimuli to the left cervical vagus and recorded compound nerve action potential (CNAP) as a measure of nerve response. We evaluated to what extent afferent or efferent pathway could be selectively activated by monophasic VNS. In a different group of rats (N = 13), we fed each rat a gadolinium‐labeled meal and scanned the rat stomach with oral contrast‐enhanced magnetic resonance imaging (MRI) while the rat was anesthetized. We evaluated the antral and pyloric motility as a function of pulse amplitude (0.13, 0.25, 0.5, 1 mA), width (0.13, 0.25, 0.5 ms), frequency (5, 10 Hz), and polarity of VNS.
Key Results
Monophasic VNS activated efferent and afferent pathways with about 67% and 82% selectivity, respectively. Primarily afferent VNS increased antral motility across a wide range of parameters. Primarily efferent VNS induced a significant decrease in antral motility as the stimulus intensity increased (R = −.93, P < .05 for 5 Hz, R = −.85, P < .05 for 10 Hz). The VNS with either polarity tended to promote pyloric motility to a greater extent given increasing stimulus intensity.
Conclusions and Inferences
Monophasic VNS biased toward the afferent pathway is potentially more effective for facilitating occlusive contractions than that biased toward the efferent pathway.
We investigated a possible differential effect of primarily afferent versus efferent cervical VNS on gastric motility under a range of VNS parameters. Gastric MRI data revealed that primarily afferent VNS induced stronger antral contractions relative to primarily efferent VNS. These results could serve as an index for optimizing VNS parameters for promoting gastric motility. </abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32297404</pmid><doi>10.1111/nmo.13853</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-6689-7058</orcidid><orcidid>https://orcid.org/0000-0002-8773-4204</orcidid><orcidid>https://orcid.org/0000-0002-0355-8515</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Neurogastroenterology and motility, 2020-07, Vol.32 (7), p.e13853-n/a |
| issn | 1350-1925 1365-2982 |
| language | eng |
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| source | Wiley:Jisc Collections:Wiley Read and Publish Open Access 2024-2025 (reading list) |
| subjects | Action potential Acute effects Electrical stimuli Food intake Gadolinium Gastric motility Magnetic resonance imaging Motility Polarity rat Rodents Sensory neurons Vagus nerve vagus nerve stimulation |
| title | Acute effects of vagus nerve stimulation parameters on gastric motility assessed with magnetic resonance imaging |
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