Squamous cell carcinoma at the site of ileo-anal pouch in Crohn’s disease

Few cases of pouch-related cancers have been reported in inflammatory bowel disease, and squamous cell carcinoma (SCC) is very rare. We have reviewed the published literature searching the online databases PubMed and Medline. Since 1979, there have been eight cases of SCC developing after restorativ...

Full description

Saved in:
Bibliographic Details
Published in:BMJ case reports 2021-02, Vol.14 (2), p.e237438
Main Authors: Condurache, Dorina Gabriela, Segal, Jonathan P, Hart, Ailsa L, Antoniou, Anthony
Format: Article
Language:English
Subjects:
Abdomen
Biopsy
Cancer therapies
Carcinoma, Squamous Cell - complications
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - therapy
Case Report
Case reports
Chemoradiotherapy, Adjuvant
Colonic Neoplasms - complications
Colonic Neoplasms - pathology
Colonic Neoplasms - therapy
Colonic Pouches - pathology
Contraindications
Crohn Disease - complications
Crohn Disease - pathology
Crohn Disease - surgery
Crohn's disease
Endoscopy
Female
Histopathology
Humans
Ileostomy
Inflammation
Inflammatory bowel disease
Laparotomy
Medical imaging
Middle Aged
Neoadjuvant Therapy
Ostomy
Patients
Proctocolectomy, Restorative
Quality of life
Radiation therapy
Risk factors
Sepsis
Squamous cell carcinoma
Surgery
Surveillance
Vagina
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Few cases of pouch-related cancers have been reported in inflammatory bowel disease, and squamous cell carcinoma (SCC) is very rare. We have reviewed the published literature searching the online databases PubMed and Medline. Since 1979, there have been eight cases of SCC developing after restorative proctocolectomy in ulcerative colitis. To date, there have been no reported cases of SCC of the ileo-anal pouch in Crohn’s disease. We present the case of a 59-year-old woman who underwent colectomy with ileal pouch-anal anastomosis for Crohn’s disease during the 1990s. The patient was noted to be anaemic and was experiencing significant weight loss with poor pouch function in 2019. Endoscopy with histology and radiological investigation revealed the presence of SCC of the pouch. This was subsequently treated with surgical therapy and chemoradiotherapy.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2020-237438