Kidney microRNA-21 Expression and Kidney Function in IgA Nephropathy

Previous studies have suggested that microRNA-21 (miR-21) plays an important role in kidney fibrosis. We examined the relationship between intrarenal miR-21 level and rate of kidney function loss in immunoglobulin A nephropathy (IgAN). Prospective cohort study. 40 patients with IgAN and 10 with hype...

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Bibliographic Details
Published in:Kidney medicine 2021-01, Vol.3 (1), p.76-82.e1
Main Authors: Szeto, Cheuk-Chun, Ng, Jack Kit-Chung, Fung, Winston Wing-Shing, Luk, Cathy Choi-Wan, Wang, Gang, Chow, Kai-Ming, Lai, Ka-Bik, Li, Philip Kam-Tao, Lai, Fernand Mac-Moune
Format: Article
Language:English
Subjects:
biomarker
chronic kidney disease
fibrosis
Glomerulonephritis
hypertension
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Summary:Previous studies have suggested that microRNA-21 (miR-21) plays an important role in kidney fibrosis. We examined the relationship between intrarenal miR-21 level and rate of kidney function loss in immunoglobulin A nephropathy (IgAN). Prospective cohort study. 40 patients with IgAN and 10 with hypertensive nephrosclerosis as controls. miR-21 levels in kidney biopsy specimen and urinary sediment, quantified as ratio to the housekeeping gene. Kidney event–free survival and rate of kidney function decline. Time-to-event and correlation analysis. The IgAN group had significantly higher intrarenal miR-21 expression compared with the hypertensive nephrosclerosis group (1.71 [IQR, 0.99-2.77] vs 0.31 [IQR, 0.25-1.32]; P
ISSN:2590-0595
2590-0595
DOI:10.1016/j.xkme.2020.11.009