A Comparison of Sphenoid Sinus Osteoneogenesis in Aspirin-Exacerbated Respiratory Disease

Background Aspirin-exacerbated respiratory disease (AERD) is characterized by excessive leukotriene production, diffuse polyp burden and osteitic bone changes. These bony changes have not been previously characterized. Objective The aim of this radiographic study is to characterize the bony changes...

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Bibliographic Details
Published in:American journal of rhinology & allergy 2021-03, Vol.35 (2), p.172-178
Main Authors: Malfitano, Madison J., Santarelli, Griffin D., Gelpi, Mark, Brown, William C., Stepp, Wesley H., Hernandez, Stephen, Kimple, Adam J., Thorp, Brian D., Zanation, Adam M., Ebert, Charles S.
Format: Article
Language:English
Subjects:
Aspirin - adverse effects
Asthma, Aspirin-Induced - diagnosis
Chronic Disease
Humans
Nasal Polyps
Original
Retrospective Studies
Rhinitis - diagnosis
Sinusitis
Sphenoid Sinus - diagnostic imaging
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Summary:Background Aspirin-exacerbated respiratory disease (AERD) is characterized by excessive leukotriene production, diffuse polyp burden and osteitic bone changes. These bony changes have not been previously characterized. Objective The aim of this radiographic study is to characterize the bony changes noted on computed tomography (CT) scans of the sphenoid sinus in patients with AERD compared to other diseased sinonasal inflammatory states and non-diseased controls. Methods A retrospective review of 43 patients with clinically confirmed AERD were included and compared to 22 non-diseased, 9 allergic fungal sinusitis, and 43 chronic rhinosinusitis controls (23 without polyps and 18 with polyps). Comparative measurements were performed using fine-cut CT scans. Sites of comparison were the intersinus septum, the left and right lateral sphenoid wall, the roof, and left and right floor of the sphenoid sinus. Standardized measurements were averaged by two separate rhinologists. Results Patients with AERD had an average statistically significant increase in bone thickness compared to healthy and diseased controls in nearly every site with the most pronounced changes in the intersinus septum (p 
ISSN:1945-8924
1945-8932
DOI:10.1177/1945892420941732