Nuclear Envelope and Nuclear Pore Complexes in Neurodegenerative Diseases—New Perspectives for Therapeutic Interventions

Transport of proteins, transcription factors, and other signaling molecules between the nucleus and cytoplasm is necessary for signal transduction. The study of these transport phenomena is particularly challenging in neurons because of their highly polarized structure. The bidirectional exchange of...

Full description

Saved in:
Bibliographic Details
Published in:Molecular neurobiology 2021-03, Vol.58 (3), p.983-995
Main Authors: Hachiya, Naomi, Sochocka, Marta, Brzecka, Anna, Shimizu, Takuto, Gąsiorowski, Kazimierz, Szczechowiak, Katarzyna, Leszek, Jerzy
Format: Article
Language:English
Subjects:
Active Transport, Cell Nucleus
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Chromatin
Cytoplasm
Gene expression
Humans
Neurobiology
Neurodegenerative diseases
Neurodegenerative Diseases - metabolism
Neurodegenerative Diseases - therapy
Neurology
Neurosciences
Nuclear Envelope - metabolism
Nuclear Pore - metabolism
Nuclear Pore Complex Proteins - metabolism
Nuclear transport
Protein transport
Proteins
RNA Transport
Signal transduction
Therapeutic applications
Transcription factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Transport of proteins, transcription factors, and other signaling molecules between the nucleus and cytoplasm is necessary for signal transduction. The study of these transport phenomena is particularly challenging in neurons because of their highly polarized structure. The bidirectional exchange of molecular cargoes across the nuclear envelope (NE) occurs through nuclear pore complexes (NPCs), which are aqueous channels embedded in the nuclear envelope. The NE and NPCs regulate nuclear transport but are also emerging as relevant regulators of chromatin organization and gene expression. The alterations in nuclear transport are regularly identified in affected neurons associated with human neurodegenerative diseases. This review presents insights into the roles played by nuclear transport defects in neurodegenerative disease, focusing primarily on NE proteins and NPCs. The subcellular mislocalization of proteins might be a very desirable means of therapeutic intervention in neurodegenerative disorders.
ISSN:0893-7648
1559-1182
DOI:10.1007/s12035-020-02168-x